Inspra

Adult Dosing .

Dosage forms:  TAB: 25 mg, 50 mg

heart failure w/ reduced ejection fraction, post-MI

[50 mg PO qd]

Start: 25 mg PO qd, incr. to 50 mg PO qd after 4wk; Max: 50 mg/day; Info: see pkg insert for dose adjustments based on potassium levels

HTN

[50 mg PO qd-bid]

Start: 50 mg PO qd, may incr. to 50 mg PO bid after 4wk; Max: 100 mg/day

hyperaldosteronism, primary (off-label)

[100-300 mg/day PO divided qd-bid]

Start: 25 mg PO bid, may incr. dose q2-4wk

renal dosing

[heart failure w/ reduced ejection fraction, post-MI]

eGFR 31-49: start 25 mg qod, may incr. to 25 mg qd after 4wk, max 25 mg/day; eGFR or CrCl <31: contraindicated

HD/PD: not defined

[all other indications]

Cr >2 (males), Cr >1.8 (females), or CrCl <50: contraindicated

HD/PD: not defined

hepatic dosing

[see below]

mild-moderate impairment: no adjustment; severe impairment: not defined

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.