Emend

Adult Dosing .

Dosage forms:  CAP: 80 mg; SUSP: 25 mg per mL; convenience pack

Special Note

[convenience pack components]

Info: 3-day pack contains 125 mg cap x1 and 80 mg cap x2

[dosing clarification]

Info: for IV fosaprepitant dosing see Emend Injection, Focinvez, or fosaprepitant; for IV aprepitant dosing see Aponvie or Cinvanti

nausea/vomiting prevention, chemo-related

[125 mg PO x1 on day 1, then 80 mg PO qam on days 2-3]

Start: 1h before chemo; Info: for pts receiving moderately- or highly-emetogenic parenteral chemo; part of multi-drug regimen; search 'CINV' for epocrates Chemo-Induced Nausea & Vomiting in Adults decision tool

nausea/vomiting prevention, postop (off-label)

[40 mg PO x1]

Start: 3h before anesthesia induction

cyclic vomiting syndrome, acute refractory (off-label)

[125 mg PO x1 on day 1, then 80 mg PO qd on days 2-3]

Start: during prodrome at least 30min before vomiting onset

cyclic vomiting syndrome prophylaxis, moderate-severe (off-label)

[40-60 kg]

Dose: 80 mg PO 2x/wk

[>60 kg]

Dose: 125 mg PO 2x/wk

renal dosing

[see below]

renal impairment: no adjustment

HD: no adjustment; no supplement; PD: not defined

hepatic dosing

[see below]

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

Peds Dosing .

Dosage forms:  CAP: 80 mg; SUSP: 25 mg per mL; convenience pack

Special Note

[convenience pack components]

Info: 3-day pack contains 125 mg cap x1 and 80 mg cap x2

[dosing clarification]

Info: for IV fosaprepitant dosing see Emend Injection, Focinvez, or fosaprepitant

nausea/vomiting prevention, chemo-related

[6 mo and older, >6 kg]

Dose: 3 mg/kg/dose PO x1 on day 1, then 2 mg/kg/dose PO qam on days 2-3; Start: 1h before chemo; Max: 125 mg on day 1, 80 mg/day on days 2-3; Info: for pts receiving moderately- or highly-emetogenic chemo; give w/ 5-HT3 antagonist and w/ or w/o corticosteroid

[12 yo and older]

Dose: 125 mg PO x1 on day 1, then 80 mg PO qam on days 2-3; Start: 1h before chemo; Info: for pts receiving moderately- or highly-emetogenic chemo; give w/ corticosteroid and 5-HT3 antagonist

cyclic vomiting syndrome, acute refractory (off-label)

[4 yo and older, <15 kg]

Dose: 80 mg PO x1 on day 1, then 40 mg PO qd on days 2-3; Start: during prodrome at least 30min before vomiting onset

[4 yo and older, 15-20 kg]

Dose: 80 mg PO qd x3 days; Start: during prodrome at least 30min before vomiting onset

[4 yo and older, >20 kg]

Dose: 125 mg PO x1 on day 1, then 80 mg PO qd on days 2-3; Start: during prodrome at least 30min before vomiting onset

cyclic vomiting syndrome prophylaxis (off-label)

[4 yo and older, <40 kg]

Dose: 40 mg PO 2x/wk

[4 yo and older, 40-60 kg]

Dose: 80 mg PO 2x/wk

[4 yo and older, >60 kg]

Dose: 125 mg PO 2x/wk

renal dosing

[see below]

renal impairment: no adjustment

HD: no adjustment; no supplement; PD: not defined

hepatic dosing

[see below]

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined