sumatriptan nasal

Adult Dosing .

Dosage forms:  SPRAY: 5 mg per actuation, 20 mg per actuation

migraine, acute

[5-20 mg intranasally x1]

Max: 40 mg/24h; Info: may repeat dose x1 after at least 2h; give 10 mg dose as 1 spray (5 mg) in each nostril x1

cluster headache, acute (off-label)

[20 mg intranasally x1]

Max: 20 mg/24h; Info: give in nostril contralateral to headache

cyclic vomiting syndrome, acute (off-label)

[20 mg intranasally x1]

Start: during prodrome or w/in 30-45min of vomiting onset; Max: 40 mg/24h, 6 doses/wk; Info: may repeat dose x1 after 2h

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[see below]

severe impairment: contraindicated

Peds Dosing .

Dosage forms:  SPRAY: 5 mg per actuation, 20 mg per actuation

migraine, acute (off-label)

[5 yo and older]

Dose: 5-20 mg intranasally x1; Max: 40 mg/24h; Info: may repeat dose x1 after at least 2h; give 10 mg dose as 1 spray (5 mg) in each nostril x1

cyclic vomiting syndrome, acute (off-label)

[12 yo and older]

Dose: 20 mg intranasally x1; Start: at episode onset

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: not defined

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance