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Desferal
deferoxamine
Adult Dosing .
Dosage forms: INJ
iron intoxication, acute
- [IM route]
- Dose: 1000 mg IM x1, may give subsequent 500 mg IM q4-12h based on clinical response; Max: 6000 mg/24h; Info: for pts not in shock
- [IV route]
- Dose: 1000 mg IV infusion x1, may give subsequent 500 mg IV infusion over 4-12h based on clinical response; Max: 6000 mg/24h, 15 mg/kg/h for initial dose, 125 mg/h for subsequent dose(s); Info: for pts in cardiovascular shock; switch to IM route as soon as pt condition permits
iron overload, chronic
- [SC route]
- Dose: 20-60 mg/kg/day SC infusion; Max: 60 mg/kg/day
- [IM route]
- Dose: 500-1000 mg IM/day; Max: 1000 mg/day
- [IV route]
- Dose: 40-50 mg/kg/day IV infusion over 8-12h; Max: 60 mg/kg/day, 15 mg/kg/h
renal dosing
- [see below]
- CrCl 10-50: decr. usual dose by 25-50%; CrCl <10: avoid use; severe renal dz, anuria: contraindicated
- HD/PD: avoid use
hepatic dosing
- [adjust dose amount]
- hepatic impairment: start at lower dose range
Peds Dosing .
- Dosage forms: INJ
iron intoxication, acute
- [IM route, 3 yo and older]
- Dose: 1000 mg IM x1, may give subsequent 500 mg IM q4-12h based on clinical response; Max: 6000 mg/24h; Info: for pts not in shock
- [IV route, 3 yo and older]
- Dose: 1000 mg IV infusion x1, may give subsequent 500 mg IV infusion over 4-12h based on clinical response; Max: 6000 mg/24h, 15 mg/kg/h for initial dose, 125 mg/h for subsequent dose(s); Info: for pts in cardiovascular shock; switch to IM route as soon as pt condition permits
iron overload, chronic
- [SC route, 3 yo and older]
- Dose: 20-40 mg/kg/day SC infusion; Max: 40 mg/kg/day
- [IM route, 3 yo and older]
- Dose: 500-1000 mg IM/day; Max: 1000 mg/day
- [IV route, 3 yo and older]
- Dose: 20-40 mg/kg/day IV infusion over 8-12h; Max: 40 mg/kg/day; Info: max 60 mg/kg/day in adolescents once growth has ceased
renal dosing
- [see below]
- CrCl 10-50: decr. usual dose by 25-50%; CrCl <10: avoid use; severe renal dz, anuria: contraindicated
- HD/PD: avoid use
hepatic dosing
- [adjust dose amount]
- hepatic impairment: start at lower dose range