alpha-tocopherol (vitamin E)

Adult Dosing .

Dosage forms:  CAP: 100 units, 200 units, 400 units, 600 units, 1000 units; TAB: 100 units, 200 units; SOL: 1150 units per 1.25 mL, 400 units per 1.2 mL, 15 units per 0.3 mL

Special Note

[strength clarification]

Info: dosage forms and doses expressed in units; 2.22 units synthetic alpha-tocopherol = 1.49 units naturally occurring alpha-tocopherol = 1 mg alpha-tocopherol

vitamin E deficiency

[60-75 units PO qd]

Max: 1000 units/day; Info: 100-400 units PO qd for cystic fibrosis; use liquid forms for malabsorption

dietary supplementation

[individualize dose]

Info: see Dietary Reference Intakes: Vitamin E (alpha-tocopherol) table

tardive dyskinesia (off-label)

[1600 units PO qd]

Info: best response if tardive dyskinesia <5y

metabolic dysfxn-associated steatohepatitis, non-diabetic pts (off-label)

[800 units PO qd]

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  CAP: 100 units, 200 units, 400 units, 600 units; TAB: 100 units, 200 units; SOL: 1150 units per 1.25 mL, 400 units per 1.2 mL, 15 units per 0.3 mL

Special Note

[strength clarification]

Info: dosage forms and doses expressed in units; 2.22 units synthetic alpha-tocopherol = 1.49 units naturally occurring alpha-tocopherol = 1 mg alpha-tocopherol

vitamin E deficiency

[premature or full-term neonates]

Dose: 25-50 units PO qd

[1 mo-12 yo]

Dose: 1 unit/kg/dose PO qd; Max: 200 units/day for 1-3 yo; 300 units/day for 4-8 yo; 600 units/day for 9-13 yo; 800 units/day for 14-18 yo; Info: for malabsorption use liquid forms

dietary supplementation

[individualize dose]

Info: see Dietary Reference Intakes: Vitamin E (alpha-tocopherol) table

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: not defined

hepatic dosing

[not defined]