Select a medication above to begin.
Wellbutrin XL
bupropion hydrochloride
Black Box Warnings .
Suicidality
incr. suicidality risk in children, adolescents, and young adults w/ major depressive or other psychiatric disorders; weigh risk vs. benefit; in short-term studies of antidepressants vs. placebo, suicidality risk not incr. in pts >24 yo, and risk decr. in pts 65 yo and older; depression and certain other psychiatric disorders themselves assoc. w/ incr. suicide risk; observe all pts for clinical worsening, suicidality, or unusual behavior changes; advise families and caregivers of need for close observation and communication w/ prescriber
Adult Dosing .
Dosage forms: ER TAB: 150 mg, 300 mg
major depressive disorder
- [300 mg PO qam]
- Start: 150 mg PO qam, may incr. to 300 mg PO qam after 4 days; Max: 450 mg/day; Info: do not cut/crush/chew tab
seasonal affective disorder
- [300 mg PO qam x4-6mo/year]
- Start: 150 mg PO qam, may incr. to 300 mg PO qam after 7 days; Max: 300 mg/day; Info: begin tx in Sep-Nov, continue through early spring; decr. dose to 150 mg/day x2wk to D/C; do not cut/crush/chew tab
ADHD (off-label)
- [300 mg PO qam]
- Start: 150 mg PO qam, may incr. to 300 mg PO qam after 7 days; Max: 450 mg/day; Info: do not cut/crush/chew tab
renal dosing
- [see below]
- renal impairment: consider decr. usual dose and/or frequency; Info: ER form cannot be cut, consider IR form for dose adjustments
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class A: consider decr. usual dose and/or frequency; Child-Pugh Class B or C: max 150 mg q48h
Peds Dosing .
- Dosage forms: ER TAB: 150 mg, 300 mg
major depressive disorder (off-label)
- [12 yo and older]
- Dose: 150-300 mg PO qam: Start: 150 mg PO qam, may incr. to 300 mg PO qam after 2wk; Info: not 1st line tx; do not cut/crush/chew tab
ADHD (off-label)
- [12 yo and older]
- Dose: 150-300 mg PO qam: Start: 150 mg PO qam, may incr. to 300 mg PO qam after 2wk; Info: do not cut/crush/chew tab
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: not defined
hepatic dosing
- [not defined]
- hepatic impairment: consider adult hepatic dosing for guidance