ursodiol

Adult Dosing .

Dosage forms:  CAP: 300 mg; TAB: 250 mg, 500 mg

gallstone dissolution

[8-10 mg/kg/day PO divided qd-tid]

Info: for radiolucent stones <20 mm; do not use tab; give w/ food; monitor response q6mo w/ ultrasound; use x3mo after dissolution

gallstone prevention

[300 mg PO bid]

Info: for obese pts during rapid wt loss; give w/ food

primary biliary cholangitis

[13-15 mg/kg/day PO divided bid-qid]

Info: give w/ food; do not crush/chew tab, but may split 500 mg tab

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  CAP: 300 mg

biliary atresia (off-label)

[<1 mo]

Dose: 20-30 mg/kg/day PO divided bid; Info: give w/ food

[1 mo and older]

Dose: 10-30 mg/kg/day PO divided bid-tid; Info: give w/ food

pruritus, cholestasis-assoc. (off-label)

[1 mo and older]

Dose: 15-30 mg/kg/day PO divided bid; Info: give w/ food

TPN-induced cholestasis (off-label)

[<1 mo]

Dose: 20-30 mg/kg/day PO divided bid; Info: give w/ food

[1 mo and older]

Dose: 30 mg/kg/day PO divided bid-tid; Info: give w/ food

liver dz, cystic fibrosis-assoc. (off-label)

[<1 mo]

Dose: 20-30 mg/kg/day PO divided bid; Info: give w/ food

[1 mo and older]

Dose: 10-30 mg/kg/day PO divided bid-tid; Info: give w/ food

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]