Actonel

Adult Dosing .

Dosage forms:  TAB: 5 mg, 30 mg, 35 mg, 150 mg

osteoporosis tx, postmenopausal

[35 mg PO qwk]

Alt: 5 mg PO qd; 150 mg PO qmo; Info: give w/ water >30min before first meal, remain upright x30min; calcium and vitamin D supplementation recommended if inadequate dietary intake; reassess need for tx in 3-5y; may consider drug holiday if stable after tx x5y (low-mod risk pt); optimal holiday duration up to 5y; if drug holiday initiated, reassess need for tx q2-4y and consider resuming tx in pts w/ fracture or significant BMD loss

osteoporosis prevention, postmenopausal

[35 mg PO qwk]

Alt: 5 mg PO qd; 150 mg PO qmo; Info: give w/ water >30min before first meal, remain upright x30min; calcium and vitamin D supplementation recommended if inadequate dietary intake; periodically reassess need for tx; consider D/C after 3-5y in low-risk pts

osteoporosis, male

[35 mg PO qwk]

Info: give w/ water >30min before first meal, remain upright x30min; calcium and vitamin D supplementation recommended if inadequate dietary intake; periodically reassess need for tx; consider D/C after 3-5y in low-risk pts

osteoporosis, steroid-induced

[5 mg PO qd]

Info: for tx and prevention in pts on >7.5 mg/day prednisone or equiv; give w/ water >30min before first meal, remain upright x30min; calcium and vitamin D supplementation recommended if inadequate dietary intake; periodically reassess need for tx; consider D/C after 3-5y in low-risk pts

Paget bone dz

[30 mg PO qd x2mo]

Info: may repeat course x1 after 2mo post-tx observation period; give w/ water >30min before first meal, remain upright x30min; calcium and vitamin D supplementation recommended if inadequate dietary intake

renal dosing

[see below]

CrCl <30: avoid use

HD/PD: not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  TAB: 5 mg, 30 mg, 35 mg, 150 mg

osteogenesis imperfecta (off-label)

[<30 kg]

Dose: 2.5 mg PO qd; Info: give w/ water >30min before first meal, remain upright x30min; calcium and vitamin D supplementation recommended if inadequate dietary intake; periodically reassess need for tx; give x1-4y

[>30 kg]

Dose: 5 mg PO qd; Info: give w/ water >30min before first meal, remain upright x30min; calcium and vitamin D supplementation recommended if inadequate dietary intake; periodically reassess need for tx; give x1-4y

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: not defined

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance