daptomycin

Adult Dosing .

Dosage forms:  INJ

skin/skin structure infections, complicated bacterial

[4 mg/kg/dose IV q24h x7-14 days]

Info: consider using adjusted wt of IBW + 0.4 x (ABW - IBW) in obese pts

bacteremia, staphylococcal

[6 mg/kg/dose IV q24h x2-6wk]

Info: consider using adjusted wt of IBW + 0.4 x (ABW - IBW) in obese pts

endocarditis, staphylococcal

[8-12 mg/kg/dose IV q24h for at least 6wk]

Info: dose, duration varies w/ pathogen susceptibility, valve type; refer to AHA guidelines; consider using adjusted wt of IBW + 0.4 x (ABW - IBW) in obese pts

endocarditis, enterococcal (off-label)

[10-12 mg/kg/dose IV q24h for at least 6wk]

Info: dose, duration varies w/ pathogen susceptibility, valve type; refer to AHA guidelines; consider using adjusted wt of IBW + 0.4 x (ABW - IBW) in obese pts

renal dosing

[adjust dose frequency]

CrCl <30: give usual dose q48h

HD: give usual dose q48h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; Alt: give usual dose 3x/wk after dialysis if on HD 3x/wk; consider giving 150% usual dose x1 after dialysis if next dialysis due in 72h; no supplement; PD: give usual dose q48h; no supplement

hepatic dosing

[see below]

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

Peds Dosing .

Dosage forms:  INJ

skin/skin structure infections, complicated bacterial

[12-23 mo]

Dose: 10 mg/kg/dose IV q24h for up to 14 days

[2-6 yo]

Dose: 9 mg/kg/dose IV q24h for up to 14 days

[7-11 yo]

Dose: 7 mg/kg/dose IV q24h for up to 14 days

[12-17 yo]

Dose: 5 mg/kg/dose IV q24h for up to 14 days

bacteremia, staphylococcal

[1-6 yo]

Dose: 12 mg/kg/dose IV q24h for up to 42 days

[7-11 yo]

Dose: 9 mg/kg/dose IV q24h for up to 42 days

[12-17 yo]

Dose: 7 mg/kg/dose IV q24h for up to 42 days

endocarditis, staphylococcal (off-label)

[1-5 yo]

Dose: 10 mg/kg/dose IV q24h for at least 6wk; Info: dose, duration varies w/ valve type; refer to AHA guidelines

[6 yo and older]

Dose: 6 mg/kg/dose IV q24h for at least 6wk; Info: dose, duration varies w/ valve type; refer to AHA guidelines

bacterial arthritis, acute (off-label)

[1-6 yo]

Dose: 12 mg/kg/dose IV q24h; Info: duration varies by infection severity

[7-11 yo]

Dose: 9 mg/kg/dose IV q24h; Info: duration varies by infection severity

[12-17 yo]

Dose: 7 mg/kg/dose IV q24h; Info: duration varies by infection severity

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance