memantine

Adult Dosing .

Dosage forms:  ER CAP: 7 mg, 14 mg, 21 mg, 28 mg; TAB: 5 mg, 10 mg; SOL: 2 mg per mL

Alzheimer dz, moderate-severe dementia

[immediate-release form]

Dose: 10 mg PO bid; Start: 5 mg PO qd, incr. by 5 mg/day no more frequently than qwk; Max: 20 mg/day; Info: give doses >5 mg/day bid

[extended-release form]

Dose: 28 mg ER PO qd; Start: 7 mg ER PO qd, incr. by 7 mg/day no more frequently than qwk; Max: 28 mg/day ER; Info: may switch from 10 mg IR tab PO bid to 28 mg ER cap PO qd starting day after last IR dose; may open cap, but do not crush/chew contents

migraine prophylaxis, episodic (off-label)

[10 mg PO qd]

Start: 5 mg PO qd, incr. dose gradually

renal dosing

[immediate-release form]

CrCl 5-29: max 10 mg/day; CrCl <5: not defined

HD/PD: not defined

[extended-release form]

CrCl 5-29: max 14 mg/day ER; CrCl <5: not defined; Info: may switch from 5 mg IR tab PO bid to 14 mg ER cap PO qd starting day after last IR dose

HD/PD: not defined

hepatic dosing

[see below]

mild-moderate impairment: no adjustment; severe impairment: not defined

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.