Leukeran

Adult Dosing .

Dosage forms:  TAB: 2 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

Hodgkin lymphoma

[0.2 mg/kg/dose PO qd x3-6wk]

non-Hodgkin lymphoma

[0.1 mg/kg/dose PO qd x3-6wk]

CLL

[0.1 mg/kg/dose PO qd x3-6wk]

Alt: start 0.4 mg/kg/dose PO x1 intermittently, q2wk, or qmo, may incr. by 0.1 mg/kg

renal dosing

[adjust dose amount]

CrCl 10-50: decr. usual dose by 25%; CrCl <10: decr. usual dose by 50%

HD: decr. usual dose by 50%; no supplement after dialysis; PD: decr. usual dose by 50%; no supplement

hepatic dosing

[see below]

hepatic impairment: consider decr. usual dose

Peds Dosing .

Dosage forms:  TAB: 2 mg

nephrotic syndrome (off-label)

[0.1-0.2 mg/kg/dose PO qd]

Info: use w/ prednisone

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]