Avastin

Adult Dosing .

Dosage forms:  INJ

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments; D/C >28 days before elective surgery, restart >28 days after major surgery when wound fully healed

colorectal CA, metastatic

[combo w/ bolus-IFL]

Dose: 5 mg/kg/dose IV x1 on day 1 of 14-day cycle

[combo w/ FOLFOX4]

Dose: 10 mg/kg/dose IV x1 on day 1 of 14-day cycle

[combo w/ fluoropyrimidine-irinotecan or fluoropyrimidine-oxaliplatin]

Dose: 5 mg/kg/dose IV x1 on day 1 of 14-day cycle; Alt: 7.5 mg/kg/dose IV x1 on day 1 of 21-day cycle; Info: for pts w/ progressive dz on bevacizumab-containing regimen

nonsquamous non-small cell lung CA, first-line tx

[15 mg/kg/dose IV x1 on day 1 of 21-day cycle]

Info: for pts w/ unresectable, locally advanced, recurrent or metastatic dz; part of multi-drug chemo regimen

glioblastoma, recurrent

[10 mg/kg/dose IV x1 on day 1 of 14-day cycle]

renal cell CA, metastatic

[10 mg/kg/dose IV x1 on day 1 of 14-day cycle]

Info: use w/ interferon alfa

cervical CA, persistent or recurrent or metastatic

[15 mg/kg/dose IV x1 on day 1 of 21-day cycle]

Info: part of multi-drug chemo regimen

ovarian CA

[stage III-IV dz]

Dose: 15 mg/kg/dose IV x1 on day 1 of 21-day cycle for up to 22 cycles; Info: for epithelial ovarian, fallopian tube, or primary peritoneal CA following initial surgical resection; part of multi-drug chemo regimen for up to 1st 6 cycles

[first-line tx, advanced homologous recombination deficiency-positive dz (off-label)]

Dose: 15 mg/kg/dose IV x1 on day 1 of 21-day cycle x15mo; Info: for epithelial ovarian, fallopian tube, or primary peritoneal CA; use w/ platinum-based chemo for at least 4 cycles, then use w/ olaparib maintenance tx for total of 15mo

[recurrent, platinum-sensitive dz]

Dose: 15 mg/kg/dose IV x1 on day 1 of 21-day cycle; Info: for epithelial ovarian, fallopian tube, or primary peritoneal CA; part of multi-drug chemo regimen for 1st 6-10 cycles

[recurrent, platinum-resistant dz, 14-day cycle]

Dose: 10 mg/kg/dose IV x1 on day 1 of 14-day cycle; Info: for epithelial ovarian, fallopian tube, or primary peritoneal CA; use w/ paclitaxel, doxorubicin liposomal, or topotecan

[recurrent, platinum-resistant dz, 21-day cycle]

Dose: 15 mg/kg/dose IV x1 on day 1 of 21-day cycle; Info: for epithelial ovarian, fallopian tube, or primary peritoneal CA; use w/ topotecan

unresectable or metastatic hepatocellular CA, first-line tx

[15 mg/kg/dose IV x1 on day 1 of 21-day cycle]

Info: use w/ atezolizumab

age-related macular degeneration, neovascular (off-label)

[1.25 mg intravitreally qmo]

Info: may decr. to 1.25 mg intravitreally x1 prn after 3 doses

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.