Agrylin

Adult Dosing .

Dosage forms:  CAP: 0.5 mg

thrombocythemia, myeloproliferative disorder-assoc.

[0.5-1 mg PO bid-qid]

Start: 0.5 mg PO qid or 1 mg PO bid, may incr. by 0.5 mg/day qwk; Max: 2.5 mg/dose up to 10 mg/day; Info: adjust dose based on Plt level; monitor Plt q2 days x1wk, then qwk until maint. dose determined; use lowest effective dose to maintain Plt <600,000

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[see below]

mild impairment: not defined, caution advised; moderate impairment: start 0.5 mg qd; severe impairment: avoid use

Peds Dosing .

Dosage forms:  CAP: 0.5 mg

thrombocythemia, myeloproliferative disorder-assoc.

[7-14 yo]

Dose: 0.5-1 mg PO bid-qid; Start: 0.5 mg PO qd, incr. by 0.5 mg/day qwk; Max: 2.5 mg/dose up to 10 mg/day; Info: adjust dose based on Plt level; monitor Plt q2 days x1wk, then qwk until maint. dose determined; use lowest effective dose to maintain Plt <600,000

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[see below]

mild impairment: not defined, caution advised; moderate impairment: start 0.5 mg qd; severe impairment: avoid use