Select a medication above to begin.
olanzapine/ fluoxetine
generic
Black Box Warnings .
Suicidality
incr. risk of suicidality in children, adolescents and young adults w/ major depressive or other psychiatric disorders esp. during 1st months of tx w/ antidepressants vs. placebo; weigh risk vs. benefit; in short-term studies of antidepressants vs. placebo, suicidality risk not incr. in pts >24 yo, and risk decr. in pts 65 yo and older; observe all pts for clinical worsening, suicidality, or unusual behavior changes; advise families and caregivers of need for close observation and communication w/ prescriber; not approved in pts <10 yo
Dementia-Related Psychosis
not approved for dementia-related psychosis; incr. mortality risk in elderly dementia pts on conventional or atypical antipsychotics; most deaths due to cardiovascular or infectious events; extent to which incr. mortality attributed to antipsychotic vs. some pt characteristic(s) not clear
Adult Dosing .
Dosage forms: CAP: 3 mg/25 mg, 6 mg/25 mg, 6 mg/50 mg, 12 mg/25 mg, 12 mg/50 mg
bipolar I disorder, acute depressive
- [6 mg/25 mg-12 mg/50 mg PO qpm]
- Start: 6 mg/25 mg PO qpm; Max: 12 mg/50 mg/day; Info: may start 3 mg/25 mg PO qpm in non-smoker, elderly or female pts or if hypotension risk; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; taper dose gradually to D/C
major depressive disorder, tx-resistant
- [6 mg/25 mg-18 mg/50 mg PO qpm]
- Start: 6 mg/25 mg PO qpm; Max: 18 mg/50 mg/day; Info: may start 3 mg/25 mg PO qpm in non-smoker, elderly or female pts or if hypotension risk; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; taper dose gradually to D/C
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- hepatic impairment: start 3 mg/25 mg-6 mg/25 mg qpm, titrate w/ caution; cirrhosis: avoid use, dose adjustment not possible w/ fixed-dose combo
Peds Dosing .
- Dosage forms: CAP: 3 mg/25 mg, 6 mg/25 mg, 6 mg/50 mg, 12 mg/25 mg, 12 mg/50 mg
bipolar I disorder, acute depressive
- [10-17 yo]
- Dose: 6 mg/25 mg-12 mg/50 mg PO qpm; Start: 3 mg/25 mg PO qpm; Max: 12 mg/50 mg/day; Info: slower titration in lower wt peds; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; taper dose gradually to D/C
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [not defined]
- hepatic impairment: consider adult hepatic dosing for guidance