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Aldactazide
spironolactone/ hydrochlorothiazide
Black Box Warnings .
Tumor Risk
spironolactone tumorigenic in chronic toxicity studies in rats; only use for approved indications and avoid unnecessary use
Not for Initial Therapy
fixed-dose combo drugs not indicated for initial tx of edema or HTN; titrate tx to individual pt, fixed-dose combo may be convenient if represents pt's dosage; reevaluate tx as pt's conditions warrant
Adult Dosing .
Dosage forms: TAB: 25 mg/25 mg, 50 mg/50 mg
HTN
- [25 mg/25 mg/day-100 mg/100 mg/day PO divided qd-bid]
edema
- [25 mg/25 mg/day-200 mg/200 mg/day PO divided qd-bid]
- Info: for pts w/ CHF, cirrhosis, or nephrotic syndrome
renal dosing
- [see below]
- renal impairment: avoid use, dose adjustment not possible w/ fixed-dose combo; Info: contraindicated if acute/significant impairment or anuria
- HD/PD: avoid use
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised; acute or severe hepatic failure: contraindicated
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.