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tinidazole
generic
Black Box Warnings .
Carcinogenic Risk
carcinogenicity in mice and rats receiving chronic metronidazole, another agent of nitroimidazole class; no similar data for tinidazole but structurally related; reserve for approved conditions; avoid chronic use
Adult Dosing .
Dosage forms: TAB: 250 mg, 500 mg
intestinal amebiasis
- [2 g PO qd x3 days]
- Info: give w/ food
amebic liver abscess
- [2 g PO qd x3-5 days]
- Info: give w/ food
giardiasis
- [2 g PO x1]
- Info: give w/ food
trichomoniasis
- [females]
- Dose: 2 g PO x1; Info: not 1st-line agent; give w/ food; give 2 g PO qd x7 days if recurrent infection and no re-exposure
- [males]
- Dose: 2 g PO x1; Info: not 1st-line agent; give w/ food
bacterial vaginosis
- [2 g PO qd x2 days]
- Alt: 1 g PO qd x5 days; Info: not 1st-line agent; give w/ food
H. pylori infection (off-label)
- [1.5-2 g/day PO divided tid-qid x14 days]
- Info: part of multi-drug regimen; search 'H. pylori Tx' for epocrates H. pylori Tx Regimens decision tool
renal dosing
- [see below]
- renal impairment: no adjustment
- HD: no adjustment, on dialysis days admin. after dialysis; give 50% usual dose as supplement if next maint. dose not due right after dialysis; PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: TAB: 250 mg, 500 mg
intestinal amebiasis
- [>3 yo]
- Dose: 50 mg/kg/dose PO qd x3 days; Max: 2 g/dose; Info: give w/ food
amebic liver abscess
- [>3 yo]
- Dose: 50 mg/kg/dose PO qd x3-5 days; Max: 2 g/dose; Info: give w/ food; monitor closely if tx >3 days
giardiasis
- [>3 yo]
- Dose: 50 mg/kg/dose PO x1; Max: 2 g/dose; Info: give w/ food
trichomoniasis (off-label)
- [female preadolescents >45 kg and adolescents]
- Dose: 2 g PO x1; Info: not 1st-line agent; give w/ food; give 2 g PO qd x7 days if recurrent infection and no re-exposure
- [male preadolescents >45 kg and adolescents]
- Dose: 2 g PO x1; Info: not 1st-line agent; give w/ food
bacterial vaginosis (off-label)
- [adolescents]
- Dose: 2 g PO qd x2 days; Alt: 1 g PO qd x5 days; Info: not 1st-line agent; give w/ food
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: consider adult renal dosing for guidance
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised