Select a medication above to begin.
ezetimibe/ simvastatin
generic
Adult Dosing .
Dosage forms: TAB: 10 mg/10 mg, 10 mg/20 mg, 10 mg/40 mg, 10 mg/80 mg
Special Note
- [restricted 10/80 mg dose]
- Info: max ezetimibe/simvastatin dose 10 mg/40 mg/day; as of 6/8/2011, any pt previously on 10 mg/80 mg/day w/o muscle toxicity x12mo may remain on this dose; do not incr. dose to 10 mg/80 mg/day in any other pts; switch to alternative tx if LDL-C goal not met on 10 mg/40 mg/day
primary hyperlipidemia
- [1 tab PO qpm]
- Max: 10 mg/40 mg/day; Info: may adjust dose q4wk; may convert from simvastatin monotherapy w/ same simvastatin dose; search 'cholesterol' for epocrates Adult Cholesterol Tx Selector decision tool
heterozygous familial hypercholesterolemia
- [1 tab PO qpm]
- Max: 10 mg/40 mg/day; Info: may adjust dose q4wk; may convert from simvastatin monotherapy w/ same simvastatin dose; search 'cholesterol' for epocrates Adult Cholesterol Tx Selector decision tool
homozygous familial hypercholesterolemia, adjunct tx
- [1 tab PO qpm]
- Max: 10 mg/40 mg/day; Info: may adjust dose q4wk; may convert from simvastatin monotherapy w/ same simvastatin dose; search 'cholesterol' for epocrates Adult Cholesterol Tx Selector decision tool
renal dosing
- [see below]
- mild impairment: no adjustment; moderate-severe impairment: not defined, caution advised if dose >10 mg/20 mg/day
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class B or C: avoid use; acute hepatic failure or decompensated cirrhosis: contraindicated
Peds Dosing .
- Dosage forms: TAB: 10 mg/10 mg, 10 mg/20 mg, 10 mg/40 mg
Special Note
- [restricted 10/80 mg dose]
- Info: max ezetimibe/simvastatin dose 10 mg/40 mg/day; as of 6/8/2011, any pt previously on 10 mg/80 mg/day w/o muscle toxicity x12mo may remain on this dose; do not incr. dose to 10 mg/80 mg/day in any other pts; switch to alternative tx if LDL-C goal not met on 10 mg/40 mg/day
heterozygous familial hypercholesterolemia
- [10 yo and older]
- Dose: 1 tab PO qpm; Max: 10 mg/40 mg/day; Info: may adjust dose q4wk; may convert from simvastatin monotherapy w/ same simvastatin dose
renal dosing
- [see below]
- mild impairment: no adjustment; moderate-severe impairment: not defined, caution advised if dose >10 mg/20 mg/day
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class B or C: avoid use; acute hepatic failure or decompensated cirrhosis: contraindicated