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Ifex
ifosfamide
Black Box Warnings .
Myelosuppression
severe cases may lead to fatal infections; monitor blood counts prior to and at intervals after each cycle
Encephalopathy
severe cases may result in death; monitor for CNS toxicity and D/C tx if encephalopathy occurs
Nephrotoxicity/Urotoxicity
severe nephrotoxicity resulting in renal failure may occur; hemorrhagic cystitis can be severe and can be reduced by prophylactic use of mesna
Adult Dosing .
Dosage forms: INJ
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments
germ cell testicular CA, refractory
- [1.2 g/m^2/dose IV x1 on days 1-5 of 21-day cycle]
- Info: use w/ mesna; maintain adequate hydration; part of multi-drug chemo regimen
renal dosing
- [adjust dose amount]
- CrCl 10-50: decr. usual dose by 25%; CrCl <10: decr. usual dose by 50%
- HD: decr. usual dose by 50%, on dialysis days admin. after dialysis; no supplement; PD: decr. usual dose by 50%; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.