methylprednisolone acetate

Adult Dosing .

Dosage forms:  INJ: 40 mg per mL, 80 mg per mL

corticosteroid-responsive conditions

[IM route]

Dose: 40-120 mg IM q1-4wk; Info: dose, frequency varies by condition; as short-term substitute for oral tx, may give equivalent dose IM; use lowest effective dose, shortest effective tx duration; taper dose gradually to D/C if high-dose or long-term use

[intra-articular route, small joints]

Dose: 4-10 mg intra-articularly x1; Info: dose, frequency varies by condition and injection site; use lowest effective dose, shortest effective tx duration; taper dose gradually to D/C if high-dose or long-term use

[intra-articular route, medium joints]

Dose: 10-40 mg intra-articularly x1; Info: dose, frequency varies by condition and injection site; use lowest effective dose, shortest effective tx duration; taper dose gradually to D/C if high-dose or long-term use

[intra-articular route, large joints]

Dose: 20-80 mg intra-articularly x1; Info: dose, frequency varies by condition and injection site; use lowest effective dose, shortest effective tx duration; taper dose gradually to D/C if high-dose or long-term use

[soft tissue injection]

Dose: 4-30 mg INJ into affected area x1; Info: dose, frequency varies by condition and injection site; use lowest effective dose, shortest effective tx duration; taper dose gradually to D/C if high-dose or long-term use

[intralesional injection]

Dose: 20-60 mg intralesionally x1; Info: dose, frequency varies by condition and injection site; use lowest effective dose, shortest effective tx duration; taper dose gradually to D/C if high-dose or long-term use

congenital adrenal hyperplasia

[40 mg IM q2wk]

Info: taper dose gradually to D/C

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ: 40 mg per mL, 80 mg per mL

corticosteroid-responsive conditions

[0.5-1.7 mg/kg/day IM x1]

Info: dose, frequency varies by condition; as short-term substitute for oral tx, may give equivalent dose IM; use lowest effective dose, shortest effective tx duration; taper dose gradually to D/C if high-dose or long-term use

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[not defined]