zolpidem

Adult Dosing .

Dosage forms:  CAP: 7.5 mg; TAB: 5 mg, 10 mg; ER TAB: 6.25 mg, 12.5 mg; SL TAB: 1.75 mg, 3.5 mg

insomnia, short-term tx

[sleep onset, female pts]

Dose: 5 mg PO qhs; Max: 10 mg/day; 12.5 mg/day ER; Alt: 6.25 mg ER PO qhs; Info: use lowest effective dose, shortest possible tx duration; give immediately before bedtime and >7h before planned awakening; give 5 mg PO qhs or 6.25 mg ER PO qhs in elderly or debilitated pts; give on empty stomach; do not cut/crush/chew ER tab; do not open cap; reevaluate if insomnia persists after 7-10 days of tx; taper dose gradually to D/C if prolonged use

[sleep onset, male pts]

Dose: 5-10 mg PO qhs; Max: 10 mg/day; 12.5 mg/day ER; Alt: 6.25-12.5 mg ER PO qhs; Info: use lowest effective dose, shortest possible tx duration; give immediately before bedtime and >7h before planned awakening; give 5 mg PO qhs or 6.25 mg ER PO qhs in elderly or debilitated pts; give on empty stomach; do not cut/crush/chew ER tab; do not open cap; reevaluate if insomnia persists after 7-10 days of tx; taper dose gradually to D/C if prolonged use

[sleep maintenance, female pts]

Dose: 6.25 mg ER PO qhs; Max: 12.5 mg/day ER; Info: use lowest effective dose, shortest possible tx duration; give immediately before bedtime and >7h before planned awakening; give 6.25 mg ER PO qhs in elderly or debilitated pts; give on empty stomach; do not cut/crush/chew ER tab; reevaluate if insomnia persists after 7-10 days of tx; taper dose gradually to D/C if prolonged use

[sleep maintenance, male pts]

Dose: 6.25-12.5 mg ER PO qhs; Max: 12.5 mg/day ER; Info: use lowest effective dose, shortest possible tx duration; give immediately before bedtime and >7h before planned awakening; give 6.25 mg ER PO qhs in elderly or debilitated pts; give on empty stomach; do not cut/crush/chew ER tab; reevaluate if insomnia persists after 7-10 days of tx; taper dose gradually to D/C if prolonged use

[middle-of-the-night waking, female pts]

Dose: 1.75 mg SL x1 per night prn; Max: 1.75 mg/day; Info: for pts w/ difficulty returning to sleep; use lowest effective dose, shortest possible tx duration; give only if >4h before planned awakening; give on empty stomach; reevaluate if insomnia persists after 7-10 days of tx; taper dose gradually to D/C if prolonged use

[middle-of-the-night waking, male pts]

Dose: 3.5 mg SL x1 per night prn; Max: 3.5 mg/day; Info: for pts w/ difficulty returning to sleep; use lowest effective dose, shortest possible tx duration; give only if >4h before planned awakening; decr. dose to 1.75 mg in elderly pts or if concurrent CNS depressant use; give on empty stomach; reevaluate if insomnia persists after 7-10 days of tx; taper dose gradually to D/C if prolonged use

renal dosing

[see below]

renal impairment: no adjustment

HD: no adjustment; no supplement; PD: not defined

hepatic dosing

[immediate-release form]

mild-moderate impairment: 5 mg qhs; severe impairment: avoid use

[extended-release form]

mild-moderate impairment: 6.25 mg ER qhs; severe impairment: avoid use

[sublingual form]

hepatic impairment: 1.75 mg x1 per night prn

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.