tranexamic acid

Adult Dosing .

Dosage forms:  TAB: 650 mg; INJ: various

dental bleeding prophylaxis, hemophilia pts

[10 mg/kg/dose IV tid-qid x2-8 days]

Start: 10 mg/kg/dose IV x1 immed. preop; Info: use w/ factor replacement tx

menorrhagia

[1300 mg PO tid during menses]

Max: 5 days

hereditary angioedema (off-label)

[0.5-3 g/day PO divided qd-tid]

Max: 1 g/dose

postpartum hemorrhage (off-label)

[1000 mg IV x1]

Start: w/in 3h of delivery; Info: may repeat x1; refer to institution protocol

hemorrhage, trauma-associated (off-label)

[1000 mg IV x1, then 1000 mg IV over 8h]

Start: w/in 3h of injury

bleeding prophylaxis, hip replacement (off-label)

[IV route]

Dose: 1000 mg IV x1 prior to incision, then may give 1000 mg IV x1 periop and/or postop; Alt: 10-15 mg/kg/dose IV x1, then 1 mg/kg/h IV infusion x10h; Info: refer to institution protocol

[topical route]

Dose: 2000 mg irrigation x1; Info: for intraop use; refer to institution protocol

bleeding prophylaxis, knee replacement (off-label)

[IV route]

Dose: 1000 mg IV x1 prior to incision, then may give 1000 mg IV x1 periop and/or postop; Alt: 10-15 mg/kg/dose IV x1, then 1 mg/kg/h IV infusion x6h; Info: refer to institution protocol

[topical route]

Dose: 2000 mg irrigation x1; Info: for intraop use; refer to institution protocol

bleeding prophylaxis, cardiac surgery (off-label)

[50 mg/kg/dose IV x1 >30min after anesthesia induction]

Alt: 30 mg/kg/dose IV x1 prior to incision, then 16 mg/kg/h IV until sternal closure; Info: refer to institution protocol; consider adding prime dose to cardiopulmonary bypass circuit

renal dosing

[dental bleeding prophylaxis]

Cr 1.36-2.83: 10 mg/kg/dose bid; Cr 2.83-5.66: 10 mg/kg/dose qd; Cr >5.66: 10 mg/kg/dose q48h or 5 mg/kg/dose qd

HD/PD: not defined

[menorrhagia]

Cr 1.41-2.8: 1300 mg bid; Cr 2.81-5.7: 1300 mg qd; Cr >5.71: 650 mg qd

HD/PD: not defined

[off-label uses]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[IV route]

hepatic impairment: not defined

[PO route]

hepatic impairment: no adjustment

Peds Dosing .

Dosage forms:  TAB: 650 mg; INJ: various

dental bleeding prophylaxis, hemophilia pts

[10 mg/kg/dose IV tid-qid x2-8 days]

Start: 10 mg/kg/dose IV x1 immed. preop; Info: use w/ factor replacement tx

menorrhagia

[postmenarchal females]

Dose: 1300 mg PO tid during menses; Max: 5 days

bleeding prophylaxis, cardiac surgery (off-label)

[2 mo and older]

Dose: 1-10 mg/kg/h IV; Start: 10-100 mg/kg/dose IV x1 after anesthesia induction; Max: 2000 mg/dose; Info: refer to institution protocol; consider adding prime dose to cardiopulmonary bypass circuit

renal dosing

[dental bleeding prophylaxis]

renal impairment: consider adult renal dosing for guidance

HD/PD: not defined

[menorrhagia]

Cr 1.41-2.8: 1300 mg bid; Cr 2.81-5.7: 1300 mg qd; Cr >5.71: 650 mg qd

HD/PD: not defined

[off-label use]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[IV route]

hepatic impairment: not defined

[PO route]

hepatic impairment: no adjustment