haloperidol lactate

Adult Dosing .

Dosage forms:  SOL: 2 mg per mL; INJ: 5 mg per mL

psychosis, acute

[parenteral route]

Dose: 2-10 mg IM/IV q4-8h; Start: 2-10 mg IM/IV q1-4h for acutely agitated pts; Max: 20 mg/day; Info: switch to PO ASAP; IV admin. not FDA-approved; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[PO route]

Dose: 0.5-5 mg PO bid-tid; Start: 0.5-2 mg PO bid-tid for moderate sx, 3-5 mg PO bid-tid for severe sx; Max: 100 mg/day for severe, refractory cases; Info: use lowest effective dose; taper dose gradually to D/C if long-term use; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

Tourette syndrome

[0.5-5 mg PO bid-tid]

Start: 0.5-2 mg PO bid-tid; Max: 100 mg/day for severe, refractory cases; Info: use lowest effective dose; taper dose gradually to D/C if long-term use; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

agitation, acute (off-label)

[0.5-10 mg PO/IM/IV q1-4h]

Max: 20 mg/day; Info: switch to PO ASAP; use lowest effective dose; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

refractory nausea/vomiting, chemo-related (off-label)

[0.5-2 mg PO/IV q4-6h]

Info: use lowest effective dose; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; search 'CINV' for epocrates Chemo-Induced Nausea & Vomiting in Adults decision tool

cannabinoid hyperemesis syndrome, acute (off-label)

[0.05-0.1 mg/kg/dose up to 5 mg IV x1]

Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  SOL: 2 mg per mL; INJ: 5 mg per mL

psychosis

[PO route, 3-12 yo, 15-40 kg]

Dose: 0.05-0.15 mg/kg/day PO divided bid-tid; Start: 0.5 mg/day PO divided bid-tid, may incr. by 0.5 mg/day q5-7 days; Info: doses >6 mg/day rarely more effective; use lowest effective dose; taper dose gradually to D/C if long-term use; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[PO route, >12 yo]

Dose: 0.5-5 mg PO bid-tid; Start: 0.5-2 mg PO bid-tid for moderate sx, 3-5 mg bid-tid for severe sx; Max: 100 mg/day for severe, refractory cases; Info: use lowest effective dose; taper dose gradually to D/C if long-term use; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[IM route, 6-12 yo (off-label)]

Dose: 1-3 mg IM q4-8h; Start: 1-3 mg IM q1h prn for acutely agitated pts; Max: 0.15 mg/kg/day; Info: switch to PO ASAP; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[IM route, >12 yo (off-label)]

Dose: 2-5 mg IM q4-8h; Start: 2-5 mg IM/IV q1h prn for acutely agitated pts; Max: 20 mg/day; Info: switch to PO ASAP; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

Tourette syndrome

[3-12 yo, 15-40 kg]

Dose: 0.05-0.075 mg/kg/day PO divided bid-tid; Start: 0.5 mg/day PO divided bid-tid, may incr. by 0.5 mg/day q5-7 days; Info: doses >6 mg/day rarely more effective; use lowest effective dose; taper dose gradually to D/C if long-term use; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[>12 yo]

Dose: 0.5-5 mg PO bid-tid; Start: 0.5-2 mg PO bid-tid; Max: 100 mg/day for severe, refractory cases; Info: use lowest effective dose; taper dose gradually to D/C if long-term use; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

behavioral disorders, severe

[3-12 yo, 15-40 kg]

Dose: 0.05-0.075 mg/kg/day PO divided bid-tid; Start: 0.5 mg/day PO divided bid-tid, may incr. by 0.5 mg/day q5-7 days; Info: doses >6 mg/day rarely more effective; use lowest effective dose; taper dose gradually to D/C if long-term use; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[>12 yo]

Dose: 0.5-5 mg PO bid-tid; Max: 100 mg/day for severe, refractory cases; Info: use lowest effective dose; taper dose gradually to D/C if long-term use; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

agitation (off-label)

[PO route, 3-12 yo]

Dose: 0.01-0.03 mg/kg/day PO divided bid-tid; Max: 0.15 mg/kg/day; Info: use lowest effective dose; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[PO route, >12 yo]

Dose: 0.5-10 mg PO q1-4h; Max: 100 mg/day for severe, refractory cases; Info: use lowest effective dose; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[IM route, 6-12 yo]

Dose: 1-3 mg IM q4-8h; Start: 1-3 mg IM q1h prn for acutely agitated pts; Max: 0.15 mg/kg/day; Info: switch to PO ASAP; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[IM route, >12 yo]

Dose: 2-5 mg IM q4-8h; Start: 2-5 mg IM/IV q1h prn for acutely agitated pts; Max: 20 mg/day; Info: switch to PO ASAP; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised