Zegerid

Adult Dosing .

Dosage forms:  CAP: 20 mg/1100 mg, 40 mg/1100 mg; PWDR: 20 mg/1680 mg per pkt, 40 mg/1680 mg per pkt

Special Note

[dosing clarification]

Info: two 20 mg cap not bioequivalent to one 40 mg cap, two 20 mg pkt not bioequivalent to one 40 mg pkt due to sodium bicarbonate component; doses based on omeprazole component

GERD

[non-erosive, symptomatic]

Dose: 20 mg PO/NG/OG qd x4-8wk; Info: give >1h before meals or if on tube feeds, suspend tube feeding 3h before and 1h after dose; do not open cap, see PPI Administration Alternatives table

[erosive esophagitis, short-term tx]

Dose: 20 mg PO/NG/OG qd x4-12wk; Info: give >1h before meals or if on tube feeds, suspend tube feeding 3h before and 1h after dose; do not open cap, see PPI Administration Alternatives table

[erosive esophagitis, maintenance tx]

Dose: 20 mg PO/NG/OG qd; Info: give >1h before meals or if on tube feeds, suspend tube feeding 3h before and 1h after dose; do not open cap, see PPI Administration Alternatives table

duodenal ulcer

[20-40 mg PO/NG/OG qd x4-8wk]

Info: usual maint. dose 20 mg PO/NG/OG qd; give >1h before meals or if on tube feeds, suspend tube feeding 3h before and 1h after dose; do not open cap, see PPI Administration Alternatives table

gastric ulcer, benign

[40 mg PO/NG/OG qd x4-8wk]

Info: give >1h before meals or if on tube feeds, suspend tube feeding 3h before and 1h after dose; do not open cap, see PPI Administration Alternatives table

upper GI bleeding prophylaxis, critically ill pts

[40 mg PO/NG/OG qd x14 days]

Start: 40 mg PO/NG/OG x1, then 40 mg PO/NG/OG x1 6-8h later; Info: give >1h before meals or if on tube feeds, suspend tube feeding 3h before and 1h after dose; do not use cap; see PPI Administration Alternatives table

gastric ulcer prophylaxis, NSAID-assoc. (off-label)

[20-40 mg PO/NG/OG qd]

Info: give >1h before meals or if on tube feeds, suspend tube feeding 3h before and 1h after dose; do not open cap, see PPI Administration Alternatives table

hypersecretory conditions (off-label)

[individualize dose PO/NG/OG qd-tid]

Start: 60 mg PO/NG/OG qd; Info: doses up to 120 mg PO tid have been used; divide doses >80 mg/day; give >1h before meals or if on tube feeds, suspend tube feeding 3h before and 1h after dose; do not open cap, see PPI Administration Alternatives table

renal dosing

[see below]

renal impairment: no adjustment; Info: caution advised, sodium bicarbonate may cause sodium retention

HD/PD: not defined

hepatic dosing

[erosive esophagitis, maintenance tx]

hepatic impairment: avoid use

[all other indications]

hepatic impairment: not defined

Peds Dosing .

Dosage forms:  CAP: 20 mg/1100 mg, 40 mg/1100 mg; PWDR: 20 mg/1680 mg per pkt, 40 mg/1680 mg per pkt

Special Note

[dosing clarification]

Info: two 20 mg cap not bioequivalent to one 40 mg cap, two 20 mg pkt not bioequivalent to one 40 mg pkt due to sodium bicarbonate component; doses based on omeprazole component

GERD, non-erosive symptomatic (off-label)

[1-16 yo, >20 kg]

Dose: 20 mg PO/NG/OG qd for up to 4wk; Alt: start 1 mg/kg/day PO/NG/OG divided qd-bid, then 0.2-3.5 mg/kg/day PO/NG/OG divided qd-bid; Info: give >1h before meals or if on tube feeds, suspend tube feeding 3h before and 1h after dose; do not open cap, see PPI Administration Alternatives table

GERD, erosive esophagitis (off-label)

[1-16 yo, >20 kg]

Dose: 20 mg PO/NG/OG qd; Alt: start 1 mg/kg/day PO/NG/OG divided qd-bid, then 0.2-3.5 mg/kg/day PO/NG/OG divided qd-bid; Info: for short-term and maintenance tx; give >1h before meals or if on tube feeds, suspend tube feeding 3h before and 1h after dose; do not open cap, see PPI Administration Alternatives table

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: not defined

hepatic dosing

[erosive esophagitis, maintenance tx]

hepatic impairment: avoid use

[all other indications]

hepatic impairment: not defined