Select a medication above to begin.
minoxidil
generic
Black Box Warnings .
Appropriate Use
admin. under close supervision usually in combo w/ therapeutic doses of beta blocker to prevent tachycardia and incr. myocardial workload; must also usually give w/ loop diuretic to prevent serious fluid accumulation; hospitalize pts w/ malignant HTN and if concomitant guanethidine for initial tx, monitor to avoid too rapid or large orthostatic decr. in blood pressure
Serious Cardiac Event Risk
powerful antihypertensive w/ serious adverse event risk incl. pericardial effusion sometimes progressing to tamponade and angina pectoris exacerbation; reserve for HTN pts w/o adequate response to max therapeutic dose of diuretic and 2 other antihypertensives; in animal studies several myocardial lesions and other cardiac adverse events occurred
Adult Dosing .
Dosage forms: TAB: 2.5 mg, 10 mg
HTN, refractory
- [5-40 mg/day PO divided qd-bid]
- Start: 5 mg PO qd, may incr. dose q3 days; Max: 100 mg/day
alopecia (off-label)
- [male pts]
- Dose: 1.25-5 mg/day PO divided qd-bid
- [female pts]
- Dose: 0.25-2.5 mg/day PO divided qd-bid
renal dosing
- [see below]
- renal failure: consider decr. usual dose
- HD: consider decr. usual dose, on dialysis days admin. after dialysis; no supplement; PD: consider decr. usual dose; no supplement
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: TAB: 2.5 mg, 10 mg
HTN, refractory
- [<12 yo]
- Dose: 0.25-1 mg/kg/day PO divided qd-bid; Start: 0.1-0.2 mg/kg/dose PO qd, may incr. dose by 0.1-0.2 mg/kg/day q3 days; Max: 50 mg/day
- [>12 yo]
- Dose: 10-40 mg/day PO divided qd-bid; Start: 5 mg PO qd, may incr. dose q3 days; Max: 100 mg/day
HTN, acute severe (off-label)
- [1 yo and older]
- Dose: 0.1-0.2 mg/kg/dose PO q8-12h; Max: 10 mg/dose; Info: for pts w/ non-life-threatening sx
renal dosing
- [see below]
- renal failure: consider decr. usual dose
- HD: consider decr. usual dose, on dialysis days admin. after dialysis; no supplement; PD: consider decr. usual dose; no supplement
hepatic dosing
- [not defined]