labetalol

Adult Dosing .

Dosage forms:  TAB: 100 mg, 200 mg, 300 mg; INJ: various

HTN

[100-400 mg PO bid]

Start: 100 mg PO bid, may incr. by 200 mg/day q2-3 days; Max 2400 mg/day; Info: may divide dose tid; taper dose over 1-2wk to D/C

hypertensive emergency

[40-80 mg IV q10min prn]

Start: 20 mg IV x1; Max: 300 mg/total dose; Alt: 2 mg/min IV

hypertensive emergency, pregnancy-assoc. (off-label)

[20-80 mg IV q10-30min prn]

Start: 10-20 mg IV x1; Max 300 mg/total dose; Alt: 1-2 mg/min IV

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  TAB: 100 mg, 200 mg, 300 mg; INJ: various

HTN (off-label)

[4 mg/kg/day PO divided bid]

Start: 1-3 mg/kg/day PO divided bid; Max: 12 mg/kg/day up to 1200 mg/24h; Info: taper dose over 1-2wk to D/C

HTN, acute severe (off-label)

[0.2-1 mg/kg/dose IV x1 prn]

Max: 40 mg/dose; 3 mg/kg/h; Alt: 0.25-3 mg/kg/h IV; Info: for pts w/ life-threatening sx; may give 0.2-1 mg/kg/dose IV x1 before IV infusion

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised