vitamin A (retinol)

Adult Dosing .

Dosage forms:  CAP: 8000 units, 10,000 units, 15,000 units, 25,000 units; TAB: 10,000 units, 15,000 units, 25,000 units

Special Note

[formulation clarification]

Info: supplements usually provide vitamin A as retinyl palmitate, retinyl acetate, or beta-carotene

[strength clarification]

Info: dosage forms and doses expressed in units; 1 unit = 0.3 mcg retinol = 0.6 mcg beta-carotene = 0.3 mcg Retinol Activity Equivalents (RAE)

vitamin A deficiency

[100,000 units PO qd x3 days, then 50,000 units PO qd x14 days]

Info: continue w/ 10,000-20,000 units PO qd x2mo

dietary supplementation

[individualize dose PO qd]

Info: see Dietary Reference Intakes: Vitamin A (retinol) table

xerophthalmia, vitamin A deficiency-assoc. (off-label)

[Dose: 200,000 units PO qd x2 days, then after 2wk 200,000 units PO x1]

vitamin A deficiency prophylaxis, high-risk pregnant pts (off-label)

[Dose: 10,000 units PO qd x12wk; Alt: 25,000 units PO qwk x12wk]

vitamin A deficiency prophylaxis, malabsorption syndromes (off-label)

[individualize dose PO qd]

Info: pts may require 10,000-100,000 units PO qd; use water-miscible vitamin A product

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  CAP: 8000 units, 10,000 units, 15,000 units, 25,000 units; TAB: 10,000 units, 15,000 units, 25,000 units

Special Note

[formulation clarification]

Info: supplements usually provide vitamin A as retinyl palmitate, retinyl acetate, or beta-carotene

[strength clarification]

Info: dosage forms and doses expressed in units; 1 unit = 0.3 mcg retinol = 0.6 mcg beta-carotene = 0.3 mcg Retinol Activity Equivalents (RAE)

vitamin A deficiency

[<1 yo]

Dose: 7500-15,000 units PO qd x10 days; Info: continue w/ 5000-10,000 units PO qd x2mo

[1-8 yo]

Dose: 17,500-35,000 units PO qd x10 days; Info: continue w/ 5000-10,000 units PO qd x2mo

[>8 yo]

Dose: 100,000 units PO qd x3 days, then 50,000 units PO qd x14 days; Info: continue w/ 10,000-20,000 units PO qd x2mo

dietary supplementation

[individualize dose PO qd]

Info: see Dietary Reference Intakes: Vitamin A (retinol) table

xerophthalmia, vitamin A deficiency-assoc. (off-label)

[<6 mo]

Dose: 50,000 units PO qd x2 days, then after 2wk 50,000 units PO x1

[6-12 mo]

Dose: 100,000 units PO qd x2 days, then after 2wk 100,000 units PO x1

[13 mo and older]

Dose: 200,000 units PO qd x2 days, then after 2wk 200,000 units PO x1

vitamin A deficiency prophylaxis, high-risk pts (off-label)

[6-11 mo]

Dose: 100,000 unit PO x1

[12-59 mo]

Dose: 200,000 units PO q4-6mo

vitamin A deficiency prophylaxis, malabsorption syndromes (off-label)

[individualize dose PO qd]

Info: pts may require 1500-15,000 units PO qd; use water-miscible vitamin A product

measles virus infection (off-label)

[<6 mo]

Dose: 50,000 units PO qd x2 days; Info: for pts w/ evidence of vitamin A deficiency give additional 50,000 units PO x1 dose at 2-6wk; refer to WHO and AAP recommendations for target populations

[6-11 mo]

Dose: 100,000 units PO qd x2 days; Info: for pts w/ evidence of vitamin A deficiency give additional 100,000 units PO x1 dose at 2-6wk; refer to WHO and AAP recommendations for target populations

[12 mo and older]

Dose: 200,000 units PO qd x2 days; Info: for pts w/ evidence of vitamin A deficiency give additional 200,000 units PO x1 dose at 2-6wk; refer to WHO and AAP recommendations for target populations

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised