Advate

Adult Dosing .

Dosage forms:  INJ

Special Note

[dosing clarification]

Info: 1 unit/kg will incr. factor VIII level approx. 2%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

hemophilia A

[bleeding episode, minor]

Dose: individualize dose IV x1; may repeat dose q12-24h until hemostasis; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 20-40%

[bleeding episode, moderate]

Dose: individualize dose IV q12-24h until hemostasis; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 30-60%

[bleeding episode, major]

Dose: individualize dose IV q8-24h until hemostasis; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 80-100%

[bleeding prophylaxis, minor surgery]

Dose: individualize dose IV x1 preop; may repeat dose q12-24h until hemostasis; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 30-60%

[bleeding prophylaxis, major surgery]

Dose: individualize dose IV x1 preop, then q8-24h until healing complete; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 80-100%

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

Special Note

[dosing clarification]

Info: 1 unit/kg will incr. factor VIII level approx. 2%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

hemophilia A

[bleeding episode, minor]

Dose: individualize dose IV x1; may repeat dose q12-24h until hemostasis; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 20-40%

[bleeding episode, moderate]

Dose: individualize dose IV q12-24h until hemostasis; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 30-60%

[bleeding episode, major]

Dose: individualize dose IV q8-24h until hemostasis; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 80-100%

[bleeding prophylaxis, minor surgery]

Dose: individualize dose IV x1 preop; may repeat dose q12-24h until hemostasis; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 30-60%

[bleeding prophylaxis, major surgery]

Dose: individualize dose IV x1 preop, then q8-24h until healing complete; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 80-100%

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]