promethazine rectal

Adult Dosing .

Dosage forms:  SUPP: 12.5 mg, 25 mg

allergic conditions

[6.25-25 mg PR tid-qid prn]

Max: 100 mg/day

motion sickness

[25 mg PR bid]

Start: 0.5-1h prior to travel

nausea/vomiting

[12.5-25 mg PR q4-6h prn]

Max: 50 mg/dose; 100 mg/day

sedation

[25-50 mg PR x1]

Max: 50 mg/dose

urticaria

[6.25-25 mg PR tid-qid prn]

Max: 100 mg/day

refractory nausea/vomiting, chemo-related (off-label)

[25 mg PR q6h]

Info: search 'CINV' for epocrates Chemo-Induced Nausea & Vomiting in Adults decision tool

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  SUPP: 12.5 mg, 25 mg

allergic conditions

[2 yo and older]

Dose: 0.1 mg/kg/dose PR q6h prn; Max: 12.5 mg/dose during day, 25 mg/dose qhs; 100 mg/day; Info: may give additional dose of up to 0.5 mg/kg/dose PR qhs; use lowest effective dose; avoid other resp. depressants

motion sickness

[2 yo and older]

Dose: 0.5 mg/kg/dose PR q12h; Start: 0.5-1h prior to travel; Max: 25 mg/dose; Info: use lowest effective dose; avoid other resp. depressants

nausea/vomiting

[2 yo and older]

Dose: 0.25-1 mg/kg/dose PR q4-6h prn; Max: 25 mg/dose; 100 mg/day; Info: use lowest effective dose; avoid other resp. depressants

sedation

[2 yo and older]

Dose: 12.5-25 mg PR x1; Max: 25 mg/dose; Info: use lowest effective dose; avoid other resp. depressants

urticaria

[2 yo and older]

Dose: 0.1 mg/kg/dose PR q6h prn; Max: 12.5 mg/dose during day, 25 mg/dose qhs; 100 mg/day; Info: may give additional dose of up to 0.5 mg/kg/dose PR qhs; use lowest effective dose; avoid other resp. depressants

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised