Boniva

Adult Dosing .

Dosage forms:  TAB: 150 mg; INJ: various

osteoporosis prevention, postmenopausal

[150 mg PO qmo]

Info: give w/ water 60min before first food/drink/med, avoid lying down x60min; calcium and vitamin D supplementation recommended if inadequate dietary intake; avoid invasive dental procedure; periodically reassess need for tx; consider D/C after 3-5y in low-risk pts

osteoporosis tx, postmenopausal

[PO route]

Dose: 150 mg PO qmo; Info: give w/ water 60min before first food/drink/med, avoid lying down x60min; calcium and vitamin D supplementation recommended if inadequate dietary intake; avoid invasive dental procedure; reassess need for tx in 3-5y; may consider drug holiday if stable after tx x5y (low-mod risk pt); optimal holiday duration up to 5y; if drug holiday initiated, reassess need for tx q2-4y and consider resuming tx in pts w/ fracture or significant BMD loss

[IV route]

Dose: 3 mg IV q3mo; Info: calcium and vitamin D supplementation recommended if inadequate dietary intake; avoid invasive dental procedure; reassess need for tx in 3y; may consider drug holiday if stable after tx x3y (low-mod risk pt); optimal holiday duration up to 5y; if drug holiday initiated, reassess need for tx q2-4y and consider resuming tx in pts w/ fracture or significant BMD loss

renal dosing

[see below]

CrCl <30: avoid use

HD/PD: not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  INJ

osteogenesis imperfecta (off-label)

[2 yo and older]

Dose: 2 mg IV q3mo; Max: 6 mg/dose; Info: give for 1-4y; calcium and vitamin D supplementation recommended if inadequate dietary intake; avoid invasive dental procedure; periodically reassess need for tx

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: not defined

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance