sodium phenylacetate/ sodium benzoate

Adult Dosing .

Dosage forms:  INJ

Special Note

[dosing clarification]

Info: 55 mL sodium phenylacetate/sodium benzoate = 5.5 g sodium phenylacetate/5.5 g sodium benzoate

acute hyperammonemia, urea cycle disorder-assoc.

[55 mL/m^2/24h IV infusion]

Start: 55 mL/m^2/dose IV x1; Info: use w/ arginine, see pkg insert

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  INJ

Special Note

[dosing clarification]

Info: 2.5 mL sodium phenylacetate/sodium benzoate = 250 mg sodium phenylacetate/250 mg sodium benzoate; 55 mL sodium phenylacetate/sodium benzoate = 5.5 g sodium phenylacetate/5.5 g sodium benzoate

acute hyperammonemia, urea cycle disorder-assoc.

[<20 kg]

Dose: 2.5 mL/kg/24h IV infusion; Start: 2.5 mL/kg/dose IV x1; Info: use w/ arginine, see pkg insert

[>20 kg]

Dose: 55 mL/m^2/24h IV infusion; Start: 55 mL/m^2/dose IV x1; Info: use w/ arginine, see pkg insert

renal dosing

[see below]

CrCl >50: no adjustment; CrCl <50: not defined, caution advised

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised