candesartan cilexetil

Adult Dosing .

Dosage forms:  TAB: 4 mg, 8 mg, 16 mg, 32 mg

HTN

[8-32 mg/day PO divided qd-bid]

Start: 16 mg PO qd, may adjust dose q2wk; Max: 32 mg/day

heart failure w/ reduced ejection fraction, NYHA Class II-IV

[32 mg PO qd]

Start: 4 mg PO qd, double dose q2wk; Max: 32 mg/day

migraine prophylaxis (off-label)

[16 mg PO qd]

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[HTN]

Child-Pugh Class B: start 8 mg qd; Child-Pugh Class C: not defined

[heart failure w/ reduced ejection fraction, NYHA Class II-IV]

hepatic impairment: not defined

Peds Dosing .

Dosage forms:  TAB: 4 mg, 8 mg, 16 mg, 32 mg

HTN

[1-5 yo]

Dose: 0.05-0.4 mg/kg/day PO divided qd-bid; Start: 0.2 mg/kg/day up to 4 mg/day PO divided qd-bid; Max: 0.4 mg/kg/day up to 16 mg/day

[6-16 yo, <50 kg]

Dose: 2-16 mg/day PO divided qd-bid; Start: 4-8 mg/day PO divided qd-bid; Max: 16 mg/day

[6-16 yo, >50 kg]

Dose: 4-32 mg/day PO divided qd-bid; Start: 8-16 mg/day PO divided qd-bid; Max: 32 mg/day

[17 yo and older]

Dose: 8-32 mg/day PO divided qd-bid; Start: 16 mg PO qd; Max: 32 mg/day

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance