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tigecycline
generic
Black Box Warnings .
All-Cause Mortality
higher in pts treated w/ tigecycline than comparators in clinical trial meta-analysis; cause of 0.6% mortality risk difference not established; reserve tigecycline for use in situations when alternative tx not suitable
Blood Glucose Test Interference
maltose contained in some tigecycline injection forms may falsely elevate glucose levels leading to unrecognized hypoglycemia or inappropriate insulin admin; use glucose testing methods that do not react w/ maltose when pts receive maltose-containing tigecycline injection form
Adult Dosing .
Dosage forms: INJ
intra-abdominal infections, complicated
- [50 mg IV q12h x5-14 days]
- Start: 100 mg IV x1; Info: not 1st-line tx; duration varies by infection site/severity
skin/skin structure infections, complicated bacterial
- [50 mg IV q12h x5-14 days]
- Start: 100 mg IV x1; Info: not 1st-line tx; duration varies by infection site/severity
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [adjust dose amount]
- Child-Pugh Class C: decr. usual maint. dose by 50%
Peds Dosing .
- Dosage forms: INJ
infections, bacterial (off-label)
- [8-11 yo]
- Dose: 1.2 mg/kg/dose IV q12h; Max: 50 mg/12h; Info: not 1st-line tx; duration varies by infection site/severity
- [12-17 yo]
- Dose: 50 mg IV q12h; Info: not 1st-line tx; duration varies by infection site/severity
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: consider adult renal dosing for guidance
hepatic dosing
- [not defined]
- hepatic impairment: consider adult hepatic dosing for guidance