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Marplan
isocarboxazid
Black Box Warnings .
Suicidality
incr. suicidality risk in children, adolescents, and young adults w/ major depressive or other psychiatric disorders; weigh risk vs. benefit; in short-term studies of antidepressants vs. placebo, suicidality risk not incr. in pts >24 yo, and risk decr. in pts 65 yo and older; depression and certain other psychiatric disorders themselves assoc. w/ incr. suicide risk; observe all pts for clinical worsening, suicidality, or unusual behavior changes; advise families and caregivers of need for close observation and communication w/ prescriber; not approved for peds use
Adult Dosing .
Dosage forms: TAB: 10 mg
depression
- [20-60 mg/day PO divided bid-qid]
- Start: 10 mg PO bid, may incr. by 10 mg/day q2-4 days; Max: 60 mg/day; Info: taper dose gradually to D/C
renal dosing
- [see below]
- mild-moderate impairment: not defined, caution advised; severe impairment: contraindicated
- HD/PD: not defined, caution advised
hepatic dosing
- [see below]
- hepatic dz hx/elevated LFTs: contraindicated
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.