Augmentin

Adult Dosing .

Dosage forms:  TAB: 250 mg/125 mg, 500 mg/125 mg, 875 mg/125 mg; SUSP: 125 mg/31.25 mg per 5 mL, 250 mg/62.5 mg per 5 mL

infections, bacterial

[500 mg/125 mg-875 mg/125 mg PO q12h]

Alt: 250 mg/125 mg-500 mg/125 mg PO q8h; Info: give w/ food or milk

sinusitis, mild-moderate acute bacterial

[<65 yo]

Dose: 875 mg/125 mg PO q12h x5-7 days; Alt: 500 mg/125 mg PO q8h x5-7 days; Info: if severe infection or 65 yo and older, use high-dose regimen w/ ER tabs avail. as generic; give w/ food or milk

UTI, uncomplicated

[500 mg/125 mg PO q12h x3-7 days]

Info: not 1st-line agent; give w/ food or milk

pneumonia, community-acquired

[500 mg/125 mg PO q8h for at least 5 days]

Alt: 875 mg/125 mg PO q12h for at least 5 days; Info: part of multi-drug regimen; refer to IDSA guidelines; give w/ food or milk

febrile neutropenia, chemo-induced (off-label)

[875 mg/125 mg PO q12h]

Info: for empiric tx in low-risk pts; give w/ ciprofloxacin or levofloxacin; give w/ food or milk

diverticulitis (off-label)

[875 mg/125 mg PO q8-12h x4-10 days]

Info: refer to AGA guidelines; give w/ food or milk

renal dosing

[see below]

CrCl 10-30: 250 mg/125 mg-500 mg/125 mg q12h; CrCl <10: 250 mg/125 mg-500 mg/125 mg q24h; Info: do not use 875 mg/125 mg tab for CrCl <30

HD: 250 mg/125 mg-500 mg/125 mg q24h, on dialysis days admin. after dialysis; consider supplement during and after dialysis if next maint. dose not due right after dialysis; PD: 250 mg/125 mg q12h; no supplement; Info: do not use 875 mg/125 mg tab

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised; amoxicillin/clavulanate-assoc. hepatic impairment hx: contraindicated

Peds Dosing .

Dosage forms:  TAB: 250 mg/125 mg, 500 mg/125 mg, 875 mg/125 mg; SUSP: 125 mg/31.25 mg per 5 mL, 250 mg/62.5 mg per 5 mL

Dosage Forms Discontinued in US

[chewable tab, 200 mg/28.5 mg per 5 mL, 400 mg/57 mg per 5 mL susp not avail. as brand; see generic]

infections, bacterial

[<3 mo]

Dose: 30 mg/kg/day PO divided q12h; Info: use 125 mg/31.25 mg/5 mL susp; dose based on amoxicillin component; give w/ food or milk

[3 mo and older, <40 kg]

Dose: 25-45 mg/kg/day PO divided q12h, use 200 mg/28.5 mg or 400 mg/57 mg forms, avail. as generic; Alt: 20-40 mg/kg/day PO divided q8h, use 125 mg/31.25 mg per 5 mL or 250 mg/62.5 mg per 5 mL susp; Info: dose based on amoxicillin component; give w/ food or milk

[3 mo and older, >40 kg]

see Adult Dosing

otitis media, acute

[3 mo-1 yo, <40 kg]

Dose: 90 mg/kg/day PO divided q12h x10 days; Info: use 600 mg/42.9 mg per 5 mL susp, avail. as other brand or generic; dose based on amoxicillin component; give w/ food or milk

[mild-moderate infection, 2-5 yo, <40 kg]

Dose: 90 mg/kg/day PO divided q12h x7 days; Info: use 600 mg/42.9 mg per 5 mL susp, avail. as other brand or generic; dose based on amoxicillin component; give w/ food or milk

[mild-moderate infection, 6-12 yo, <40 kg]

Dose: 90 mg/kg/day PO divided q12h x5-7 days; Info: use 600 mg/42.9 mg per 5 mL susp, avail. as other brand or generic; dose based on amoxicillin component; give w/ food or milk

[severe infection, 2-12 yo, <40 kg]

Dose: 90 mg/kg/day PO divided q12h x10 days; Info: use 600 mg/42.9 mg per 5 mL susp, avail. as other brand or generic; dose based on amoxicillin component; give w/ food or milk

sinusitis, acute bacterial

[3 mo-1 yo]

Dose: 90 mg/kg/day PO divided q12h x10-14 days; Info: use 600 mg/42.9 mg per 5 mL susp, avail. as other brand or generic; dose based on amoxicillin component; give w/ food or milk

[mild-moderate infection, 2 yo and older]

Dose: 45 mg/kg/day PO divided q12h x10-14 days; Info: use 200 mg/28.5 mg or 400 mg/57 mg forms, avail. as generic; dose based on amoxicillin component; treat as severe infection in pts w/ daycare attendance, high risk of PCN-resistant S. pneumoniae, abx use w/in 1mo, recent hospitalization, or immunocompromised; give w/ food or milk

[severe infection, 2 yo and older, <40 kg]

Dose: 90 mg/kg/day PO divided q12h x10-14 days; Info: use 600 mg/42.9 mg per 5 mL susp, avail. as other brand or generic; dose based on amoxicillin component; give w/ food or milk

[severe infection, 2 yo and older, >40 kg]

Dose: 2000 mg/125 mg ER PO q12h x10-14 days; Info: use 1000 mg/62.5 mg ER tab, avail. as generic; give w/ food or milk

UTI

[2 mo-2 yo]

Dose: 20-40 mg/kg/day PO divided q8h x7-14 days; Info: dose based on amoxicillin component; if wt <40 kg, use 125 mg/31.25 mg per 5 mL or 250 mg/62.5 mg per 5 mL susp; duration varies w/ infection type, severity; give w/ food or milk

community-acquired pneumonia, mild-moderate bacterial

[>3 mo, <40 kg (off-label)]

Dose: 90 mg/kg/day PO divided q12h x5-10 days; Max: 4000 mg/day; Info: dose based on amoxicillin component; use 600 mg/42.9 mg per 5 mL susp, avail. as other brand or generic; if wt >40 kg, give 2000 mg/125 mg ER PO q12h x7-10 days; use 1000 mg/62.5 mg ER tab, avail. as generic; give w/ food or milk

febrile neutropenia, chemo-induced (off-label)

[45-90 mg/kg/day PO divided q12h]

Info: for empiric tx in low-risk pts; give w/ ciprofloxacin; dose based on amoxicillin component; if 45 mg/kg/day regimen, use 200 mg/28.5 mg or 400 mg/57 mg forms, avail. as generic; if 90 mg/kg/day regimen and wt <40 kg, use 600 mg/42.9 mg per 5 mL susp, avail. as other brand or generic, max 2 g/dose; if 90 mg/kg/day regimen and wt >40 kg, give 2000 mg/125 mg ER PO q12h; use 1000 mg/62.5 mg ER tab, avail. as generic; give w/ food or milk

renal dosing

[see below]

CrCl 10-30: 8-20 mg/kg/dose q12h; CrCl <10: 8-20 mg/kg/dose q24h; Info: dose based on amoxicillin component; do not use 875 mg/125 mg tab if CrCl <30

HD: 8-20 mg/kg/dose q24h, on dialysis days admin. after dialysis; consider supplement during and after dialysis if next maint. dose not due right after dialysis; PD: 8-20 mg/kg/dose q24h; no supplement; Info: dose based on amoxicillin component; do not use 875 mg/125 mg tab

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised; amoxicillin/clavulanate-assoc. hepatic impairment hx: contraindicated