Select a medication above to begin.
naproxen sodium
generic
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, incl. MI and stroke; risk may occur early in tx and may incr. w/ duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events incl. bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and w/o warning sx; elderly pts and pts w/ hx of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: CAP: 220 mg; TAB: 220 mg, 275 mg, 550 mg; ER TAB: 375 mg, 500 mg
Special Note
- [strength clarification]
- Info: 220, 275, 550 mg naproxen sodium = 200, 250, 500 mg naproxen; IR doses expressed as naproxen sodium; ER doses expressed as naproxen equivalents
osteoarthritis
- [220-550 mg PO q12h]
- Max: 1650 mg/day up to 6mo; 1500 mg/day ER for <6mo; Alt: 220 mg PO q8h or 750-1000 mg ER PO qd; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
rheumatoid arthritis
- [220-550 mg PO q12h]
- Max: 1650 mg/day up to 6mo; 1500 mg/day ER for <6mo; Alt: 220 mg PO q8h or 750-1000 mg ER PO qd; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
ankylosing spondylitis
- [275-550 mg PO q12h]
- Max: 1650 mg/day up to 6mo; 1500 mg/day ER for <6mo; Alt: 220 mg PO q8h or 750-1000 mg ER PO qd; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
gout, acute
- [275 mg PO q8h]
- Start: 825 mg x1; Alt: 550 mg PO bid or start 1000-1500 mg ER PO qd x1, then 1000 mg ER PO qd; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
pain, mild-moderate
- [220-550 mg PO q12h]
- Max: 1375 mg/day acute; 1100 mg/day maint; 1500 mg/day ER for limited periods; Alt: start 550 mg PO x1, then 275 mg PO q6-8h; start 440 mg PO x1, then 220 mg PO q8h; 1000 mg ER PO qd; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
dysmenorrhea
- [220-550 mg PO q12h]
- Max: 1375 mg/day; 1500 mg/day ER for limited periods; Alt: start 550 mg PO x1, then 275 mg PO q6-8h; start 440 mg PO x1, then 220 mg PO q8h; 1000 mg ER PO qd; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
fever
- [220 mg PO q8-12h]
- Start: 440 mg PO x1; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
for anti-inflammatory uses
- [275-550 mg PO q12h]
- Max: 1375 mg/day acute; 1100 mg/day maint; 1500 mg/day ER for limited periods; Alt: 1000 mg ER PO qd; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
renal dosing
- [see below]
- CrCl >60: no adjustment; CrCl 30-60: not defined, caution advised; CrCl <30: avoid use
- HD/PD: avoid use
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: CAP: 220 mg; TAB: 220 mg, 275 mg, 550 mg
Special Note
- [strength clarification]
- Info: 220, 275, 550 mg naproxen sodium = 200, 250, 500 mg naproxen
juvenile idiopathic arthritis
- [2 yo and older]
- Dose: 11 mg/kg/day PO divided q12h; Max: 1100 mg/day; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
pain, mild-moderate
- [2 yo and older]
- Dose: 11-22 mg/kg/day PO divided q8-12h; Max: 1100 mg/day; Alt: 440 mg PO x1, then 220 mg PO q8-12h; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
fever
- [2 yo and older]
- Dose: 11-22 mg/kg/day PO divided q8-12h; Max: 1100 mg/day; Alt: 440 mg PO x1, then 220 mg PO q8-12h; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
renal dosing
- [see below]
- CrCl >60: no adjustment; CrCl 30-60: not defined, caution advised; CrCl <30: avoid use
- HD/PD: avoid use
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised