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Arranon
nelarabine
Black Box Warnings .
Severe Neurologic Events
incl. altered mental states, severe somnolence, CNS effects incl. seizures, and peripheral neuropathy ranging from numbness and paresthesia to motor weakness and paralysis; some events assoc. w/ demyelination or ascending peripheral neuropathies similar in appearance to Guillain-Barre syndrome; not always full recovery w/ D/C tx; monitor closely for neurologic events; D/C tx if events of NCI common toxicity criteria >grade 2
Adult Dosing .
Dosage forms: INJ
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, and dosing incl. toxicity-related dose adjustments
T-ALL/T-LBL, refractory or relapsed
- [1500 mg/m^2/dose IV x1 on days 1, 3, 5 of 21-day cycle]
- Info: for pts who have received at least 2 lines of tx
renal dosing
- [see below]
- CrCl >50: no adjustment; CrCl <50: not defined, caution advised
- HD/PD: not defined, caution advised
hepatic dosing
- [see below]
- bilirubin >3x ULN: not defined, caution advised
Peds Dosing .
- Dosage forms: INJ
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, and dosing incl. toxicity-related dose adjustments
T-ALL/T-LBL, refractory or relapsed
- [1 yo and older]
- Dose: 650 mg/m^2/dose IV x1 on days 1-5 of 21-day cycle; Info: for pts who have received at least 2 lines of tx
renal dosing
- [see below]
- CrCl >50: no adjustment; CrCl <50: not defined, caution advised
- HD/PD: not defined, caution advised
hepatic dosing
- [see below]
- bilirubin >3x ULN: not defined, caution advised