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Amitiza
lubiprostone
Adult Dosing .
Dosage forms: CAP: 8 mcg, 24 mcg
chronic idiopathic constipation
- [24 mcg PO bid]
- Info: give w/ food and water; do not open cap; periodically reassess need for tx
constipation, opioid-induced
- [24 mcg PO bid]
- Info: for pts w/ chronic non-cancer pain, incl. pain related to prior cancer or tx; give w/ food and water; do not open cap; periodically reassess need for tx
IBS, constipation-predominant
- [8 mcg PO bid]
- Info: for female pts; give w/ food and water; do not open cap; periodically reassess need for tx
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [IBS, constipation-predominant]
- Child-Pugh Class C: 8 mcg qd; Info: may incr. to 8 mcg bid if tolerated and inadequate response
- [all other indications]
- Child-Pugh Class B: 16 mcg bid; Child-Pugh Class C: 8 mcg bid; Info: may incr. up to 24 mcg bid if tolerated and inadequate response
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.