Orencia

Adult Dosing .

Dosage forms:  INJ (ClickJect auto-injector): 125 mg; INJ (pre-filled syringe): 125 mg per mL; INJ (vial): various

rheumatoid arthritis, mod-severe

[IV route, <60 kg]

Dose: 500 mg IV q4wk; Start: 500 mg IV x1 on wk 0, 2, 4, then q4wk; Info: may transition from IV to SC dosing at next scheduled IV dose

[IV route, 60-100 kg]

Dose: 750 mg IV q4wk; Start: 750 mg IV x1 on wk 0, 2, 4, then q4wk; Info: may transition from IV to SC dosing at next scheduled IV dose

[IV route, >100 kg]

Dose: 1000 mg IV q4wk; Start: 1000 mg IV x1 on wk 0, 2, 4, then q4wk; Info: may transition from IV to SC dosing at next scheduled IV dose

[SC route, <60 kg]

Dose: 125 mg SC qwk; Info: may start 500 mg IV x1, then 125 mg SC x1 w/in 24h, then 125 mg SC qwk

[SC route, 60-100 kg]

Dose: 125 mg SC qwk; Info: may start 750 mg IV x1, then 125 mg SC x1 w/in 24h, then 125 mg SC qwk

[SC route, >100 kg]

Dose: 125 mg SC qwk; Info: may start 1000 mg IV x1, then 125 mg SC x1 w/in 24h, then 125 mg SC qwk

psoriatic arthritis

[IV route, <60 kg]

Dose: 500 mg IV q4wk; Start: 500 mg IV x1 on wk 0, 2, 4, then q4wk; Info: may transition from IV to SC dosing at next scheduled IV dose

[IV route, 60-100 kg]

Dose: 750 mg IV q4wk; Start: 750 mg IV x1 on wk 0, 2, 4, then q4wk; Info: may transition from IV to SC dosing at next scheduled IV dose

[IV route, >100 kg]

Dose: 1000 mg IV q4wk; Start: 1000 mg IV x1 on wk 0, 2, 4, then q4wk; Info: may transition from IV to SC dosing at next scheduled IV dose

[SC route]

Dose: 125 mg SC qwk

GVHD prophylaxis, acute

[10 mg/kg/dose IV x1 on the day before transplantation (day -1), then 10 mg/kg/dose IV x1 on days 5, 14, 28 after transplantation]

Max: 1000 mg/dose; Info: for pts undergoing HSCT from a matched or 1 allele-mismatched unrelated-donor; use w/ methotrexate and a calcineurin inhibitor; give EBV antiviral prophylaxis before tx and x6mo following HSCT; consider CMV antiviral prophylaxis during tx and x6mo following HSCT

COVID-19 (off-label)

[10 mg/kg/dose IV x1]

Max: 1000 mg/dose; Info: for hospitalized pts w/ severe COVID-19 requiring supplemental oxygen but not mechanical ventilation or extracorporeal membrane oxygenation (ECMO); not 1st-line agent

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ (ClickJect auto-injector): 125 mg; INJ (pre-filled syringe): 50 mg per 0.4 mL, 87.5 mg per 0.7 mL, 125 mg per mL; INJ (vial): various

polyarticular juvenile idiopathic arthritis, mod-severe

[IV route, 6-17 yo, <75 kg]

Dose: 10 mg/kg/dose IV q4wk; Start: 10 mg/kg/dose IV x1 on wk 0, 2, 4, then q4wk

[IV route, 6-17 yo, 75-100 kg]

Dose: 750 mg IV q4wk; Start: 750 mg IV x1 on wk 0, 2, 4, then q4wk

[IV route, 6-17 yo, >100 kg]

Dose: 1000 mg IV q4wk; Start: 1000 mg IV x1 on wk 0, 2, 4, then q4wk; Max: 1000 mg/dose

[SC route, 2-17 yo, 10-24 kg]

Dose: 50 mg SC qwk

[SC route, 2-17 yo, 25-49 kg]

Dose: 87.5 mg SC qwk

[SC route, 2-17 yo, >50 kg]

Dose: 125 mg SC qwk

GVHD prophylaxis, acute

[2-6 yo]

Dose: 15 mg/kg/dose IV x1 on the day before transplantation (day -1), then 12 mg/kg/dose IV x1 on days 5, 14, 28 after transplantation; Info: for pts undergoing HSCT from a matched or 1 allele-mismatched unrelated-donor; use w/ methotrexate and a calcineurin inhibitor; give EBV antiviral prophylaxis before tx and x6mo following HSCT; consider CMV antiviral prophylaxis during tx and x6mo following HSCT

[6 yo and older]

Dose: 10 mg/kg/dose IV x1 on the day before transplantation (day -1), then 10 mg/kg/dose IV x1 on days 5, 14, 28 after transplantation; Max: 1000 mg/dose; Info: for pts undergoing HSCT from a matched or 1 allele-mismatched unrelated-donor; use w/ methotrexate and a calcineurin inhibitor; give EBV antiviral prophylaxis before tx and x6mo following HSCT; consider CMV antiviral prophylaxis during tx and x6mo following HSCT

psoriatic arthritis

[2-17 yo, 10-24 kg]

Dose: 50 mg SC qwk

[2-17 yo, 25-49 kg]

Dose: 87.5 mg SC qwk

[2-17 yo, >50 kg]

Dose: 125 mg SC qwk

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]