Aloprim

Adult Dosing .

Dosage forms:  INJ

hyperuricemia, chemo-related

[200-400 mg/m^2/day IV divided q6-24h]

Start: 24-48h before chemo; Max: 600 mg/day; Info: maintain urine output >2 L/day, neutral/slightly alkaline urine pH; cont. until able to tolerate PO tx or TLS risk abated

renal dosing

[see below]

CrCl 10-20: 200 mg q24h; CrCl <10: 100 mg q24h

HD: 50 mg q12h or 100 mg q24h; no supplement after dialysis; PD: not defined

hepatic dosing

[see below]

hepatic dz: not defined, caution advised

Peds Dosing .

Dosage forms:  INJ

hyperuricemia, chemo-related

[200 mg/m^2/day IV divided q6-24h]

Start: 24-48h before chemo; Max: 400 mg/day; Info: maintain adequate urine output, neutral/slightly alkaline urine pH; cont. until able to tolerate PO tx or TLS risk abated

renal dosing

[not defined]

renal impairment: not defined, consider adult renal dosing for guidance

HD: not defined, consider adult renal dosing for guidance; PD: not defined

hepatic dosing

[see below]

hepatic dz: not defined, caution advised