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Emsam
selegiline transdermal
Black Box Warnings .
Suicidality
incr. suicidality risk in children, adolescents, and young adults w/ major depressive or other psychiatric disorders; weigh risk vs. benefit; in short-term studies of antidepressants vs. placebo, suicidality risk not incr. in pts >24 yo, and risk decr. in pts 65 yo and older; depression and certain other psychiatric disorders themselves assoc. w/ incr. suicide risk; observe all pts for clinical worsening, suicidality, or unusual behavior changes; advise families and caregivers of need for close observation and communication w/ prescriber; contraindicated in pts <12 yo due to incr. hypertensive crisis risk
Adult Dosing .
Dosage forms: PATCH: 6 mg per 24h, 9 mg per 24h, 12 mg per 24h
major depressive disorder
- [apply 1 patch qd]
- Start: apply 6 mg patch qd, may incr. by 3 mg/24h q2wk; Max: 12 mg/24h; Info: do not cut patch; taper dose gradually to D/C
renal dosing
- [see below]
- eGFR 15-89: no adjustment; eGFR <15: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- mild-moderate impairment: no adjustment; severe impairment: not defined
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.