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Ultram ER
tramadol
Black Box Warnings .
Brand Discontinued in US
select or search generic name for alternatives
Contraindications / Cautions .
- Brand Discontinued in US
Drug Interactions .
Overview
tramadol
opioid
- CYP2D6 substrate
- CYP3A4 substrate
- antidiuretic hormone effects
- CNS depression
- decreases gastrointestinal motility
- hypoglycemic effects
- hyponatremia
- hypotensive effects
- lowers seizure threshold
- opioid agonist
- potentiates neuromuscular blockade
- prolongs QT interval (known)
- serotonergic effects
- urinary retention
- consider prescribing naloxone, esp. w/ concomitant CNS depressant use
- add MAO inhibitor to Interaction Check if recent (14 days) use
Contraindicated
- cisapride
- domperidone
- dronedarone
- fluconazole
- isocarboxazid
- isoniazid
- levoketoconazole
- linezolid
- methylene blue injection
- methylene blue oral
- naltrexone
- phenelzine
- pimozide
- posaconazole
- potassium chloride
- potassium citrate
- procarbazine
- quinidine (CYP2D6 inhibitor)
- rasagiline
- safinamide
- samidorphan
- selegiline
- selegiline transdermal
- thioridazine
- tranylcypromine
- yohimbe
Avoid/Use Alternative
- 5-HTP
- abiraterone acetate
- adagrasib
- aldesleukin
- alfentanil
- almotriptan
- alprazolam
- amifampridine
- amiodarone
- amitriptyline
- amoxapine
- amphetamine
- anagrelide
- apalutamide
- apomorphine
- aprepitant
- arsenic trioxide
- artemether/lumefantrine
- asenapine
- atazanavir
- azithromycin
- baclofen intrathecal
- bedaquiline
- benztropine
- berberine
- berotralstat
- bosentan
- brexanolone
- bromocriptine
- buprenorphine
- bupropion
- buspirone
- butalbital
- butorphanol
- cabozantinib
- capivasertib
- carbamazepine
- celecoxib
- cenobamate
- ceritinib
- chloramphenicol
- chlordiazepoxide
- chloroquine
- chlorpromazine
- cimetidine
- cinacalcet
- ciprofloxacin
- citalopram
- clarithromycin
- clobazam
- clofazimine
- clomipramine
- clonazepam
- clopidogrel
- clorazepate
- clozapine
- cobicistat
- cocaine
- codeine
- conivaptan
- crizotinib
- cyclobenzaprine
- cyclosporine
- dabrafenib
- dacomitinib
- danazol
- darifenacin
- darunavir
- degarelix
- desflurane
- desipramine
- desvenlafaxine
- dexmedetomidine
- dexmedetomidine injection
- dexmethylphenidate
- dextroamphetamine
- dextromethorphan
- diazepam
- dihydrocodeine
- dihydroergotamine
- diltiazem
- diphenhydramine
- disopyramide
- dofetilide
- donepezil
- doxepin
- doxepin topical
- doxylamine
- droperidol
- duloxetine
- duvelisib
- efavirenz
- eletriptan
- eliglustat
- eluxadoline
- enasidenib
- encorafenib
- entrectinib
- enzalutamide
- ephedra
- epirubicin
- ergotamine
- eribulin
- erythromycin
- escitalopram
- esketamine
- estazolam
- ethanol
- ethinyl estradiol (contraceptive)
- etrasimod
- etravirine
- fedratinib
- felodipine
- fenfluramine
- fentanyl
- fexinidazole
- flecainide
- fluorouracil
- fluoxetine
- fluvoxamine
- fosamprenavir
- foscarnet
- fosphenytoin
- frovatriptan
- gabapentin
- gefitinib
- gepirone
- gilteritinib
- ginkgo
- givinostat
- givosiran
- glasdegib
- goserelin
- granisetron
- grapefruit
- haloperidol
- histrelin
- hydralazine
- hydrocodone
- hydromorphone
- hydroxychloroquine
- hydroxyzine
- ibutilide
- idelalisib
- iloperidone
- imatinib
- imipramine
- inotuzumab ozogamicin
- iohexol
- isavuconazonium
- itraconazole
- ivabradine
- ivosidenib
- kava
- ketamine
- ketoconazole
- kratom
- labetalol
- lasmiditan
- lefamulin
- lenacapavir
- letermovir
- leuprolide
- levofloxacin
- levomilnacipran
- levorphanol
- lisdexamfetamine
- lithium
- lofexidine
- lonafarnib
- loperamide
- lopinavir/ritonavir
- lorazepam
- lorlatinib
- lumacaftor/ivacaftor
- macimorelin
- mavacamten
- mavorixafor
- meperidine
- metaxalone
- methadone
- methamphetamine
- methohexital
- methylergonovine
- methylphenidate
- metoclopramide
- midazolam
- mifepristone
- milnacipran
- mirabegron
- mirtazapine
- mitapivat
- mitotane
- mobocertinib
- modafinil
- morphine
- moxifloxacin
- nafcillin
- nalbuphine
- naratriptan
- nefazodone
- nelfinavir
- netupitant
- nilotinib
- nirogacestat
- nortriptyline
- oliceridine
- ondansetron
- opium
- osilodrostat
- osimertinib
- oxazepam
- oxybate
- oxycodone
- oxymorphone
- ozanimod
- pacritinib
- paliperidone
- palonosetron
- panobinostat
- paroxetine
- pasireotide
- pazopanib
- pentamidine
- pentazocine
- pentobarbital
- pexidartinib
- phenobarbital
- phenytoin
- pimavanserin
- pitolisant
- ponesimod
- pramlintide
- prasugrel
- pregabalin
- primidone
- procainamide
- prochlorperazine
- promethazine
- propafenone
- propranolol
- protriptyline
- quazepam
- quetiapine
- quinidine (antiarrhythmic)
- quinine
- quizartinib
- ranolazine
- remifentanil
- remimazolam
- repotrectinib
- revefenacin inhaled
- ribociclib
- rifabutin
- rifampin
- rifapentine
- ritonavir
- rizatriptan
- rolapitant
- romidepsin
- ropeginterferon alfa-2b
- rucaparib
- SAMe
- saquinavir
- selpercatinib
- sertraline
- siponimod
- solifenacin
- sorafenib
- sotalol
- sotorasib
- St. John's wort
- sufentanil
- sumatriptan
- tapentadol
- telavancin
- temazepam
- terbinafine
- tetrabenazine
- thalidomide
- ticagrelor
- tipranavir
- toremifene
- tramadol
- trazodone
- triazolam
- triclabendazole
- trifluridine
- trimipramine
- triptorelin
- tucatinib
- vandetanib
- vemurafenib
- venlafaxine
- verapamil
- vilazodone
- viloxazine
- voriconazole
- vortioxetine
- ziprasidone
- zolmitriptan
- zuranolone
Monitor/Modify Tx
- acebutolol
- acetazolamide
- albuterol
- albuterol inhaled
- alfuzosin
- aliskiren
- allopurinol
- alogliptin
- amantadine
- amifostine
- amiloride
- amisulpride
- amlodipine
- apraclonidine ophthalmic
- arformoterol inhaled
- aripiprazole
- aripiprazole bimonthly injection
- aripiprazole lauroxil
- articaine
- asciminib
- atenolol
- atracurium
- avanafil
- azilsartan medoxomil
- baclofen
- benazepril
- betaxolol
- betaxolol ophthalmic
- bethanechol
- bexagliflozin
- bisoprolol
- bortezomib
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- brompheniramine
- bumetanide
- bupivacaine
- bupivacaine liposomal
- cabergoline
- canagliflozin
- candesartan cilexetil
- cannabidiol
- cannabis
- captopril
- carbinoxamine
- cariprazine
- carisoprodol
- carteolol ophthalmic
- carvedilol
- cetirizine
- chamomile, German
- chloroprocaine
- chlorothiazide
- chlorpheniramine
- chlorthalidone
- chlorzoxazone
- cilostazol
- cisatracurium
- cisplatin
- clemastine
- clevidipine
- clofarabine
- clonidine
- coenzyme Q-10
- colesevelam
- cyclophosphamide
- cyproheptadine
- dantrolene
- dapagliflozin
- daridorexant
- dasatinib
- desmopressin
- deutetrabenazine
- dexchlorpheniramine
- dichlorphenamide
- difelikefalin
- difenoxin
- digoxin
- dimenhydrinate
- dinutuximab
- diphenoxylate
- dipyridamole
- doxazosin
- dronabinol
- empagliflozin
- enalapril
- enalaprilat
- entacapone
- eplerenone
- epoprostenol
- ertugliflozin
- eslicarbazepine acetate
- esmolol
- eszopiclone
- ethacrynic acid
- ethanol (in some formulations)
- ethosuximide
- etomidate
- exenatide
- felbamate
- fenoldopam
- ferumoxytol
- fesoterodine
- fingolimod
- flaxseed
- flibanserin
- fluphenazine
- formoterol inhaled
- fosinopril
- fostemsavir
- furosemide
- gabapentin enacarbil
- ganaxolone
- garlic
- gemtuzumab ozogamicin
- glimepiride
- glipizide
- glofitamab
- glyburide
- glycopyrrolate
- guanfacine
- hydrochlorothiazide
- hyoscyamine
- ifosfamide
- iloprost
- iloprost inhaled
- indapamide
- insulin
- iopamidol
- irbesartan
- iron sucrose
- isoflurane
- isosorbide dinitrate
- isosorbide mononitrate
- isradipine
- lacosamide
- lamotrigine
- lapatinib
- lemborexant
- lenvatinib
- levalbuterol inhaled
- levetiracetam
- levobunolol ophthalmic
- levocetirizine
- levodopa
- lidocaine
- linagliptin
- liraglutide
- lisinopril
- losartan
- loxapine
- lubiprostone
- lumateperone
- lurasidone
- magnesium citrate
- magnesium sulfate
- mannitol
- maraviroc
- meclizine
- mefloquine
- melatonin
- mepivacaine
- meprobamate
- methazolamide
- methocarbamol
- methsuximide
- methyldopa
- metolazone
- metoprolol
- metronidazole
- metyrapone
- metyrosine
- midostaurin
- milrinone
- minoxidil
- moexipril
- molindone
- mosunetuzumab
- mycophenolate mofetil
- nadolol
- nateglinide
- nattokinase
- nebivolol
- nelarabine
- niacin (vitamin B3)
- nicardipine
- nifedipine
- nimodipine
- nisoldipine
- nitric oxide
- nitrite
- nitroglycerin
- nitroprusside
- ofloxacin
- olanzapine
- olmesartan medoxomil
- olodaterol inhaled
- opicapone
- orphenadrine
- oxaliplatin
- oxcarbazepine
- oxybutynin
- oxytocin
- pamabrom
- pancuronium
- passion flower
- perampanel
- perindopril
- perphenazine
- pheniramine
- phenoxybenzamine
- phentolamine
- pindolol
- pioglitazone
- polyethylene glycol
- polyethylene glycol/electrolytes
- pralsetinib
- pramipexole
- prazosin
- primaquine
- propofol
- pyrilamine
- quinapril
- ramelteon
- ramipril
- ramucirumab
- relugolix
- repaglinide
- rilpivirine
- riociguat
- risperidone
- rocuronium
- ropinirole
- ropivacaine
- rosiglitazone
- rotigotine transdermal
- rufinamide
- sacituzumab govitecan
- sacubitril
- salmeterol inhaled
- saxagliptin
- scopolamine
- selinexor
- semaglutide
- sevoflurane
- sildenafil
- silodosin
- sitagliptin
- sodium ferric gluconate complex
- sotagliflozin
- sparsentan
- spironolactone
- stiripentol
- succinylcholine
- sulfate bowel prep
- sunitinib
- suvorexant
- tacrolimus
- tadalafil
- tagraxofusp
- tamsulosin
- tasimelteon
- taurine
- tazemetostat
- telmisartan
- terazosin
- terbutaline
- thiothixene
- tiagabine
- timolol
- timolol ophthalmic
- tizanidine
- tolcapone
- tolterodine
- topiramate
- torsemide
- trandolapril
- treprostinil
- triamterene
- trifluoperazine
- trihexyphenidyl
- trimethobenzamide
- triprolidine
- trospium
- valbenazine
- valerian
- valproic acid
- valsartan
- vardenafil
- vasopressin
- vecuronium
- vigabatrin
- vilanterol inhaled
- voclosporin
- vosoritide
- warfarin
- zaleplon
- ziconotide
- zolpidem
- zonisamide
Caution Advised
- aclidinium inhaled
- acyclovir
- alosetron
- aminophylline
- amoxicillin
- ampicillin
- armodafinil
- atropine
- axicabtagene ciloleucel
- barium
- belladonna alkaloids
- belzutifan
- benzphetamine
- betamethasone
- bexarotene
- botulinum toxin
- brexucabtagene autoleucel
- brigatinib
- busulfan
- cefazolin
- cefepime
- cefiderocol
- ceftaroline fosamil
- ceftazidime
- chlorambucil
- ciltacabtagene autoleucel
- clidinium
- cortisone
- dalfampridine
- danshen
- darbepoetin alfa
- darolutamide
- deflazacort
- delafloxacin
- dexamethasone
- dicloxacillin
- dicyclomine
- diethylpropion
- echinacea
- elafibranor
- elagolix
- elivaldogene autotemcel
- epoetin alfa
- erenumab
- ertapenem
- flavoxate
- galantamine
- ganciclovir
- ginseng, Asian
- glycerol phenylbutyrate
- glycopyrrolate inhaled
- glycopyrronium topical
- griseofulvin
- homatropine
- hydrocortisone
- idecabtagene vicleucel
- imipenem
- interferon beta 1a
- interferon beta 1b
- ipratropium inhaled
- ketorolac
- levocarnitine
- lidocaine topical
- lindane topical
- lisocabtagene maraleucel
- meropenem
- methotrexate
- methoxy polyethylene glycol-epoetin beta
- methscopolamine
- methylprednisolone
- mexiletine
- nafarelin
- nevirapine
- olutasidenib
- omaveloxolone
- oxacillin
- penicillin G
- penicillin V
- phendimetrazine
- phentermine
- piperacillin
- potassium acid phosphate
- potassium gluconate
- potassium phosphate
- prednisolone
- prednisone
- pyridostigmine
- pyrimethamine
- regadenoson
- rivastigmine
- sarilumab
- sodium phenylbutyrate/taurursodiol
- sodium phosphate (bowel prep)
- sodium picosulfate
- somatropin
- teclistamab
- tecovirimat
- telotristat ethyl
- theophylline
- tiotropium inhaled
- tisagenlecleucel
- tocilizumab
- tovorafenib
- tranexamic acid
- triamcinolone
- umeclidinium inhaled
- vaborbactam
- valacyclovir
- valganciclovir
- vamorolone
- varenicline
- vinblastine
- zanubrutinib
Adverse Reactions .
Serious Reactions
- Brand Discontinued in US
Common Reactions
- Brand Discontinued in US
Safety/Monitoring .
Brand Discontinued in US
Look/Sound-Alike Drug Names
traMADol confused with: Toprol-XL; Toradol; trandolapril; traZODone; Voltaren
Formulary .
No Formulary Selected
Manufacturer/Pricing .
Manufacturer: Janssen Pharmaceuticals, Inc.
DEA/FDA: Discontinued
Approximate Retail Price
This information is currently not available for this drug.
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