Vectibix

Adult Dosing .

Dosage forms:  INJ

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

colorectal CA, metastatic

[RAS wild-type dz, first-line tx]

Dose: 6 mg/kg/dose IV x1 on day 1 of 14-day cycle; Info: use w/ FOLFOX as part of multi-drug chemo regimen

[RAS wild-type dz, previously treated dz]

Dose: 6 mg/kg/dose IV x1 on day 1 of 14-day cycle; Info: use as monotherapy in pts who have progressed after fluoropyrimidine-, oxaliplatin- and irinotecan-based tx

[KRAS G12C-mutated dz, previously treated dz]

Dose: 6 mg/kg/dose IV x1 on day 1 of 14-day cycle; Info: for pts who have received prior fluoropyrimidine-, oxaliplatin-, and irinotecan-based tx; use w/ sotorasib

renal dosing

[see below]

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

hepatic dosing

[see below]

bilirubin 1-3x ULN: no adjustment; bilirubin >3x ULN: not defined

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.