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Invega
paliperidone
Black Box Warnings .
Dementia-Related Psychosis
not approved for dementia-related psychosis; incr. mortality risk in elderly pts on antipsychotic tx for dementia-related psychosis; most deaths due to cardiovascular or infectious events
Adult Dosing .
Dosage forms: ER TAB: 3 mg, 6 mg, 9 mg
Dosage Forms Discontinued in US
- [1.5 mg ER tab not avail. as brand; see generic]
schizophrenia
- [6 mg PO qam]
- Max: 12 mg/day; Info: may titrate by 3 mg/day no more frequently than q5 days; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; do not cut/crush/chew tab
schizoaffective disorder
- [6 mg PO qam]
- Max: 12 mg/day; Info: for acute tx as monotherapy or adjunct to mood stabilizers and/or antidepressants; may titrate by 3 mg/day no more frequently than q4 days; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; do not cut/crush/chew tab
renal dosing
- [see below]
- CrCl 50-79: start 3 mg qam, max 6 mg/day; CrCl 10-49: start 1.5 mg qam, max 3 mg/day; CrCl <10: avoid use
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined
Peds Dosing .
- Dosage forms: ER TAB: 3 mg, 6 mg, 9 mg
Dosage Forms Discontinued in US
- [1.5 mg ER tab not avail. as brand; see generic]
schizophrenia
- [12-17 yo]
- Dose: 3 mg PO qam; Max: 12 mg/day; Info: may titrate by 3 mg/day no more frequently than q5 days; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; do not cut/crush/chew tab
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: not defined
hepatic dosing
- [not defined]
- hepatic impairment: consider adult hepatic dosing for guidance