BeneFIX

Adult Dosing .

Dosage forms:  INJ

Special Note

[dosing clarification]

Info: 1 unit/kg will incr. factor IX level approx. 0.8%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

hemophilia B

[bleeding episode, minor]

Dose: individualize dose IV q12-24h x1-2 days until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.3] where desired factor IX level 20-30%

[bleeding episode, moderate]

Dose: individualize dose IV q12-24h x2-7 days until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.3] where desired factor IX level 25-50%

[bleeding episode, major]

Dose: individualize dose IV q12-24h x7-10 days until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.3] where desired factor IX level 50-100%

[bleeding prophylaxis, minor surgery]

Dose: individualize dose IV x1 preop, then cont. q12-24h x1-2 days until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.3] where desired factor IX level 20-30%

[bleeding prophylaxis, moderate surgery]

Dose: individualize dose IV x1 preop, then cont. q12-24h x2-7 days until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.3] where desired factor IX level 25-50%

[bleeding prophylaxis, major surgery]

Dose: individualize dose IV x1 preop, then cont. q12-24h x7-10 days until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.3] where desired factor IX level 50-100%

[bleeding prophylaxis, routine]

Dose: 100 units/kg/dose IV qwk; Info: adjust dose based on clinical response

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  INJ

Special Note

[dosing clarification]

Info: 1 unit/kg will incr. factor IX level approx. 0.7% for pts <12 yo and 0.8% for pts 12 yo and older; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

hemophilia B

[bleeding episode, minor, <12 yo]

Dose: individualize dose IV q12-24h x1-2 days until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.4] where desired factor IX level 20-30%

[bleeding episode, minor, 12 yo and older]

Dose: individualize dose IV q12-24h x1-2 days until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.3] where desired factor IX level 20-30%

[bleeding episode, moderate, <12 yo]

Dose: individualize dose IV q12-24h x2-7 days until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.4] where desired factor IX level 25-50%

[bleeding episode, moderate, 12 yo and older]

Dose: individualize dose IV q12-24h x2-7 days until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.3] where desired factor IX level 25-50%

[bleeding episode, major, <12 yo]

Dose: individualize dose IV q12-24h x7-10 days until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.4] where desired factor IX level 50-100%

[bleeding episode, major, 12 yo and older]

Dose: individualize dose IV q12-24h x7-10 days until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.3] where desired factor IX level 50-100%

[bleeding prophylaxis, minor surgery, <12 yo]

Dose: individualize dose IV x1 preop, then cont. q12-24h x1-2 days until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.4] where desired factor IX level 20-30%

[bleeding prophylaxis, minor surgery, 12 yo and older]

Dose: individualize dose IV x1 preop, then cont. q12-24h x1-2 days until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.3] where desired factor IX level 20-30%

[bleeding prophylaxis, moderate surgery, <12 yo]

Dose: individualize dose IV x1 preop, then cont. q12-24h x2-7 days until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.4] where desired factor IX level 25-50%

[bleeding prophylaxis, moderate surgery, 12 yo and older]

Dose: individualize dose IV x1 preop, then cont. q12-24h x2-7 days until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.3] where desired factor IX level 25-50%

[bleeding prophylaxis, major surgery, <12 yo]

Dose: individualize dose IV x1 preop, then cont. q12-24h x7-10 days until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.4] where desired factor IX level 50-100%

[bleeding prophylaxis, major surgery, 12 yo and older]

Dose: individualize dose IV x1 preop, then cont. q12-24h x7-10 days until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1.3] where desired factor IX level 50-100%

[bleeding prophylaxis, routine, 16 yo and older]

Dose: 100 units/kg/dose IV qwk; Info: adjust dose based on clinical response

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised