Coreg CR

Adult Dosing .

Dosage forms:  ER CAP: 10 mg, 20 mg, 40 mg, 80 mg

HTN

[initial tx]

Dose: 20-80 mg PO qam; Start: 20 mg PO qam, may double dose q1-2wk; Max: 80 mg/day; Info: give w/ food; taper dose over 1-2wk to D/C

[conversion from IR form]

Dose: 20-80 mg PO qam; Max: 80 mg/day; Info: 6.25 mg/day IR = 10 mg/day ER; may incr. dose q1-2wk; in pts 65 yo and older or at risk of hypotension, dizziness, or syncope on 25 mg/day IR or 50 mg/day IR, switch to 20 mg/day ER or 40 mg/day ER, respectively, then may incr. dose q2wk; give w/ food; taper dose over 1-2wk to D/C

heart failure w/ reduced ejection fraction

[initial tx]

Dose: 80 mg PO qam; Start: 10 mg PO qam, may double dose q2wk; Max: 80 mg/day; Info: minimize fluid retention prior to tx; give w/ food; taper dose over 1-2wk to D/C

[conversion from IR form]

Dose: 80 mg PO qam; Max: 80 mg/day; Info: 6.25 mg/day IR = 10 mg/day ER; may incr. dose q2wk; in pts 65 yo and older or at risk of hypotension, dizziness, or syncope on 25 mg/day IR or 50 mg/day IR, switch to 20 mg/day ER or 40 mg/day ER, respectively, then may incr. dose q2wk; minimize fluid retention prior to tx; give w/ food; taper dose over 1-2wk to D/C

left ventricular dysfxn, post-MI

[initial tx]

Dose: 80 mg PO qam; Start: 20 mg PO qam ASAP after pt stable, then double dose q3-10 days; Info: minimize fluid retention prior to tx; start 10 mg PO qam and/or titrate slower if fluid retention, hypotension, or bradycardia; give w/ food; taper dose over 1-2wk to D/C

[conversion from IR form]

Dose: 80 mg PO qam; Info: 6.25 mg/day IR = 10 mg/day ER; incr. dose q3-10 days; in pts 65 yo and older or at risk of hypotension, dizziness, or syncope on 25 mg/day IR or 50 mg/day IR, switch to 20 mg/day ER or 40 mg/day ER, respectively, then incr. dose q2wk; minimize fluid retention prior to tx; give w/ food; taper dose over 1-2wk to D/C

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: avoid use

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.