Select a medication above to begin.
Soliris
eculizumab
Black Box Warnings .
Appropriate Use
restricted distribution program (Ultomiris and Soliris REMS) due to meningococcal infection risk; prescribers, healthcare settings, pharmacies must enroll at 1-888-765-4747 or www.ultsolrems.com
Serious Meningococcal Infection
life-threatening and fatal cases have occurred; may become rapidly life-threatening or fatal if not recognized and treated early; complete or update vaccination for meningococcal bacteria serogroups A, C, W, Y, and B at least 2wk before tx start, unless tx delay risks outweigh infection risk; provide antibacterial prophylaxis if urgent tx indicated in pts not up to date w/ meningococcal vaccines, and admin. vaccines ASAP; comply w/ ACIP recommendations for meningococcal vaccination in pts receiving complement inhibitor; revaccinate per ACIP recommendations, considering tx duration; vaccination does not eliminate meningococcal infection risk despite antibodies developed after vaccination; monitor for early signs of meningococcal infection and eval. immediately if infection suspected
Adult Dosing .
Dosage forms: INJ
Restricted Distribution in US
- [1-888-765-4747 or www.ultsolrems.com for more info]
paroxysmal nocturnal hemoglobinuria
- [900 mg IV q2wk]
- Start: 600 mg IV qwk x4wk, then 900 mg IV qwk x1wk, then 900 mg IV q2wk
atypical hemolytic uremic syndrome
- [1200 mg IV q2wk]
- Start: 900 mg IV qwk x4wk, then 1200 mg IV qwk x1wk, then 1200 mg IV q2wk; Info: see pkg insert for supplemental dose if plasmapheresis, plasma exchange, plasma infusion, or IVIG
generalized myasthenia gravis
- [1200 mg IV q2wk]
- Start: 900 mg IV qwk x4wk, then 1200 mg IV qwk x1wk, then 1200 mg IV q2wk; Info: for anti-acetylcholine receptor antibody positive pts; see pkg insert for supplemental dose if plasmapheresis, plasma exchange, plasma infusion, or IVIG
neuromyelitis optica spectrum disorder
- [1200 mg IV q2wk]
- Start: 900 mg IV qwk x4wk, then 1200 mg IV qwk x1wk, then 1200 mg IV q2wk; Info: for anti-aquaporin-4 antibody positive pts; see pkg insert for supplemental dose if plasmapheresis, plasma exchange, plasma infusion, or IVIG
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ
Restricted Distribution in US
- [1-888-765-4747 or www.ultsolrems.com for more info]
atypical hemolytic uremic syndrome
- [2 mo and older, 5-9 kg]
- Dose: 300 mg IV qwk x1 dose, then start maint. dose at 300 mg IV x1 on wk 2, then 300 mg IV q3wk; Info: see pkg insert for supplemental dose if plasmapheresis, plasma exchange, plasma infusion, or IVIG
- [2 mo and older, 10-19 kg]
- Dose: 600 mg IV qwk x1 dose, then start maint. dose at 300 mg IV x1 on wk 2, then 300 mg IV q2wk; Info: see pkg insert for supplemental dose if plasmapheresis, plasma exchange, plasma infusion, or IVIG
- [2 mo and older, 20-29 kg]
- Dose: 600 mg IV qwk x2 doses, then start maint. dose at 600 mg IV x1 on wk 3, then 600 mg IV q2wk; Info: see pkg insert for supplemental dose if plasmapheresis, plasma exchange, plasma infusion, or IVIG
- [2 mo and older, 30-39 kg]
- Dose: 600 mg IV qwk x2 doses, then start maint. dose at 900 mg IV x1 on wk 3, then 900 mg IV q2wk; Info: see pkg insert for supplemental dose if plasmapheresis, plasma exchange, plasma infusion, or IVIG
- [2 mo and older, >40 kg]
- Dose: 900 mg IV qwk x4 doses, then start maint. dose at 1200 mg IV x1 on wk 5, then 1200 mg IV q2wk; Info: see pkg insert for supplemental dose if plasmapheresis, plasma exchange, plasma infusion, or IVIG
generalized myasthenia gravis
- [6 yo and older, 10-19 kg]
- Dose: 600 mg IV qwk x1 dose, then start maint. dose at 300 mg IV x1 on wk 2, then 300 mg IV q2wk; Info: see pkg insert for supplemental dose if plasmapheresis, plasma exchange, plasma infusion, or IVIG
- [6 yo and older, 20-29 kg]
- Dose: 600 mg IV qwk x2 doses, then start maint. dose at 600 mg IV x1 on wk 3, then 600 mg IV q2wk; Info: see pkg insert for supplemental dose if plasmapheresis, plasma exchange, plasma infusion, or IVIG
- [6 yo and older, 30-39 kg]
- Dose: 600 mg IV qwk x2 doses, then start maint. dose at 900 mg IV x1 on wk 3, then 900 mg IV q2wk; Info: see pkg insert for supplemental dose if plasmapheresis, plasma exchange, plasma infusion, or IVIG
- [6 yo and older, >40 kg]
- Dose: 900 mg IV qwk x4 doses, then start maint. dose at 1200 mg IV x1 on wk 5, then 1200 mg IV q2wk; Info: see pkg insert for supplemental dose if plasmapheresis, plasma exchange, plasma infusion, or IVIG
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [not defined]