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Black Box Warnings .
Potential for Carcinogenicity
metronidazole shown to be carcinogenic in mice and rats; unknown if metronidazole is associated w/ carcinogenicity in humans
Adult Dosing .
Dosage forms: CAP: 140 mg/125 mg/125 mg
H. pylori infection
- [3 caps PO qid x10-14 days]
- Info: give w/ omeprazole 20 mg PO bid x10-14 days; give w/ full glass of water after meals and at bedtime; do not open cap; search 'H. pylori Tx' for epocrates H. pylori Tx Regimens decision tool
renal dosing
- [see below]
- mild-moderate impairment: avoid use, dose adjustment not possible w/ fixed-dose combo; severe impairment: contraindicated
- HD/PD: avoid use, dose adjustment not possible w/ fixed-dose combo
hepatic dosing
- [see below]
- mild-moderate impairment: not defined, caution advised; severe impairment: avoid use, dose adjustment not possible w/ fixed-dose combo
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.