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Black Box Warnings .
Fetal Toxicity
fetal/neonatal morbidity/mortality may occur when drugs that act directly on the renin-angiotensin system are used in pregnancy; D/C drug ASAP once pregnancy detected
Adult Dosing .
Dosage forms: TAB: 5 mg/20 mg, 5 mg/40 mg, 10 mg/20 mg, 10 mg/40 mg
HTN
- [1 tab PO qd]
- Start: 5 mg/20 mg PO qd, may incr. dose after 1-2wk; Max: 10 mg/40 mg/day; Info: avoid initial tx in pts 75 yo and older as lower amlodipine dose not possible w/ fixed-dose combo
renal dosing
- [see below]
- CrCl >20: no adjustment; CrCl <20: not defined, caution advised
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: avoid use as initial tx, lower amlodipine dose not possible w/ fixed-dose combo
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.