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diclofenac potassium
generic
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, incl. MI and stroke; risk may occur early in tx and may incr. w/ duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events incl. bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and w/o warning sx; elderly pts and pts w/ hx of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: CAP: 25 mg; TAB: 50 mg; PWDR: 50 mg per pkt
Special Note
- [formulation clarification]
- Info: diclofenac potassium products may not be interchangeable w/ other diclofenac potassium, diclofenac sodium, or diclofenac products; reassess dose if switching between products
pain, mild-moderate
- [capsule form]
- Dose: 25 mg PO qid; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs; D/C if abnormal liver or renal tests persist or worsen
- [tablet form]
- Dose: 50 mg PO tid; Start: may consider 100 mg PO x1; Max: 200 mg/day 1st 24h only, 150 mg/day thereafter; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs; D/C if abnormal liver or renal tests persist or worsen
dysmenorrhea, primary
- [50 mg tab PO tid]
- Start: may consider 100 mg tab PO x1; Max: 200 mg/day 1st 24h only, 150 mg/day thereafter; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs; D/C if abnormal liver or renal tests persist or worsen
osteoarthritis
- [50 mg tab PO bid-tid]
- Max: 150 mg/day; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs; D/C if abnormal liver or renal tests persist or worsen
rheumatoid arthritis
- [50 mg tab PO tid-qid]
- Max: 200 mg/day; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs; D/C if abnormal liver or renal tests persist or worsen
migraine, acute
- [50 mg PO x1]
- Info: give on empty stomach, but may give w/ food if GI upset occurs; D/C if abnormal liver or renal tests persist or worsen
renal dosing
- [see below]
- CrCl <30: avoid use; advanced renal dz: avoid use
- HD/PD: avoid use
hepatic dosing
- [adjust dose amount]
- hepatic impairment: decr. usual dose, amount not defined
Peds Dosing .
- Dosage forms: CAP: 25 mg; TAB: 50 mg
Special Note
- [formulation clarification]
- Info: diclofenac potassium products may not be interchangeable w/ other diclofenac potassium, diclofenac sodium, or diclofenac products; reassess dose if switching between products
pain, mild-moderate
- [12 yo and older]
- Dose: 25 mg cap PO qid; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs; D/C if abnormal liver or renal tests persist or worsen
juvenile idiopathic arthritis (off-label)
- [14 yo and older]
- Dose: 75-100 mg/day PO divided bid-tid; Max: 150 mg/day; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs; D/C if abnormal liver or renal tests persist or worsen
renal dosing
- [see below]
- CrCl <30: avoid use; advanced renal dz: avoid use
- HD/PD: avoid use
hepatic dosing
- [adjust dose amount]
- hepatic impairment: decr. usual dose, amount not defined