Select a medication above to begin.
Pristiq
desvenlafaxine
Black Box Warnings .
Suicidality
incr. suicidality risk in children, adolescents, and young adults w/ major depressive or other psychiatric disorders; weigh risk vs. benefit; in short-term studies of antidepressants vs. placebo, suicidality risk not incr. in pts >24 yo, and risk decr. in pts 65 yo and older; depression and certain other psychiatric disorders themselves assoc. w/ incr. suicide risk; observe all pts for clinical worsening, suicidality, or unusual behavior changes; advise families and caregivers of need for close observation and communication w/ prescriber; not approved for peds use
Adult Dosing .
Dosage forms: ER TAB: 25 mg, 50 mg, 100 mg
major depressive disorder
- [50 mg PO qd]
- Info: no proven additional benefit at doses >50 mg/day; do not cut/crush/chew/dissolve tab; taper dose gradually to D/C
neuropathic pain, diabetic (off-label)
- [200 mg PO qd]
- Start: 50-100 mg PO qd, incr. dose q3 days; Info: do not cut/crush/chew/dissolve tab; taper dose gradually to D/C
vasomotor sx, mod-severe menopausal (off-label)
- [100-150 mg PO qd]
- Start: 25-50 mg PO qd, incr. dose by 25-50 mg/day q24h; Info: do not cut/crush/chew/dissolve tab; taper dose gradually to D/C
renal dosing
- [see below]
- CrCl 30-50: max 50 mg/day; CrCl <30 or ESRD: max 25 mg/day or 50 mg qod
- HD: max 25 mg/day or 50 mg qod; no supplement after dialysis; PD: max 25 mg/day or 50 mg qod; no supplement
hepatic dosing
- [adjust dose amount]
- moderate-severe impairment: max 100 mg/day
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.